Sandbox: maria4
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| Outcome | Intensive | Standard | HR | CI | P value | NNT/NNH |
|---|---|---|---|---|---|---|
| Primary outcome | ||||||
| First ACS, stroke, HF, or CV death | 5.20% | 6.80% | 0.75 | 0.64-0.89 | P<0.001 | 63 |
| Secondary outcome | ||||||
| MI | 2.10% | 2.50% | 0.83 | 0.64-1.09 | P=0.19 | |
| ACS without MI | 0.90% | 0.90% | 1 | 0.64-1.55 | P=0.99 | |
| Stroke | 1.30% | 1.50% | 0.89 | 0.62-1.25 | P=0.50 | |
| HF | 1.30% | 2.10% | 0.62 | 0.45-0.84 | P=0.002 | 125 |
| CV mortality | 0.80% | 1.40% | 0.57 | 0.38-0.85 | P=0.005 | 167 |
| All-cause mortality | 3.30% | 4.50% | 0.73 | 0.60-0.90 | P=0.003 | 83 |
| Composite of primary outcome or all-cause mortality | 7.10% | 9.00% | 0.78 | 0.67-0.90 | P<0.001 | 53 |
| Of those with CKD at baseline: | ||||||
| ≥50% reduction in GFR, long-term HD, or renal transplant | 1.10% | 1.10% | 0.89 | 0.42-1.87 | P=0.76 | |
| ≥50% reduction in GFR | 0.80% | 0.80% | 0.87 | 0.36-2.07 | P=0.75 | |
| Long-term HD | 0.50% | 0.80% | 0.57 | 0.19-2.54 | 0.27 | |
| Renal transplant | none | none | none | none | none | |
| New albuminuria | 9.30% | 11.80% | 0.72 | 0.48-1.07 | P=0.11 | |
| Of those without CKD at baseline | ||||||
| ≥30% reduction in GFR to <60 mL/min/1.73 m2 | 3.80% | 1.10% | 3.49 | 2.44-5.10 | P<0.001 | 37 |
| New albuminuria | 6.20% | 7.40% | 0.81 | 0.63-1.04 | P=0.10 | |