Sandbox: table

• VIDEO - Neuroblastoma, Jeannie Yang, MD, gives an overview at the University of Wisconsin Department of Surgery Grand Rounds (2007)

Seven subtypes of neuroblastic tumors are recognized according to the degree of neuroblastic maturation and the amount of background schwannian stroma

Neuroblastoma, undifferentiated Composed entirely of neuroblasts, no ganglion cell maturation Immunohistochemistry is often required to confirm neuroblastic lineage Schwannian stroma poor Less than 50% of background stroma is schwannian May be absent Neuroblastoma, poorly differentiated Predominantly neuroblasts,

<5% maturing/mature ganglion cells

At least one focus of neuropilSchwannian stroma poor Less than 50% of background stroma is schwannian May be absent Neuroblastoma, differentiating Predominantly neuroblasts but >5% maturing/mature ganglion cells At least one focus of neuropil Schwannian stroma poor Less than 50% of background stroma is schwannian May be absent