Sandbox chemo1

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards

• Chlorambucil (Leukeran)
• Cyclophosphamide (Cytoxan)
• Ifosfamide (Iflex)
• Melphalan (Alkeran)
• Mechlorethamine (Mustargen)

Ethylenimines

• Thiotepa (Tepadina)

Methylhydrazines

• Procarbazine (Matulane)

Alkylsulfonates

• Busulfan (Myleran)

Nitrosoureas

• Bendamustine (Treanda)
• Carmustine (BiCNU)
• Lomustine (CeeNU)
• Streptozocin (Zanosar)

Triazenes

• Altretamine (Hexalen)
• Dacarbazine (Dtic-Dome)
• Temozolomide (Temodar)

Platinum coordination complexes

• Carboplatin (Paraplatin)
• Cisplatin (Platinol)
• Oxaliplatin (Eloxatin)

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Antimetabolites

Folic acid analogs

• Methotrexate (Mexate, Folex)
• Pemetrexed (Alimta)

Pyrimidine analogs

• Azacytidine (Vidaza)
• Capecitabine (Xeloda)
• Cytarabine (Cytosar)
• Floxuridine (FUDR)
• Fluorouracil (Adrucil, Efudex)
• Gemcitabine (Gemzar)

Purine analogs

• Cladribine (Leustatin)
• Clofarabine (Clolar)
• Fludarabine (Fludara)
• Mercaptopurine (Purinethol)
• Nelarabine (Arranon)
• Pentostatin (Nipent)
• Thioguanine (Tabloid)

Ribonucleotide reductase inhibitors

• Hydroxyurea (Hydrea)

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Natural products

Vinca alkaloids

• Vinblastine (Velban, Velsar)
• Vincristine (Oncovin, Vincasar)
• Vincristine liposome (Marqibo)
• Vinorelbine (Navelbine)

Taxanes

• Docetaxel (Taxotere)
• Paclitaxel (Taxol, Onxol)

Epipodophyllotoxins

• Etoposide (Vespid)
• Teniposide (Vumon)

Camptothecins

• Irinotecan (Camptosar)
• Topotecan (Hycamtin)

Anthracyclines

• Bleomycin (Blenoxane)
• Dactinomycin (Cosmegen)
• Daunorubicin (Daunoxome)
• Doxorubicin (Adriamycin, Rubex)
• Epirubicin (Ellence)
• Idarubicin (Idamycin)
• Mitomycin C (Mutamycin)
• Mitoxantrone (Novantrone)
• Valrubicin (Valstar)

Antineoplastic enzymes

• L-Asparaginase (Elspar)
• Pegaspargase (Oncaspar)
• Glucarpidase (Voraxaze)

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Hormones and Antagonists

Adrenocortical suppressants

• Mitotane (Lysodren)

Adrenocortico-steroids

• Prednisone (Deltasone)

Progestins

• Medroxyprogesterone (Provera)
• Megestrol (Megace)

Anti-estrogens

• Tamoxifen (Nolvadex)
• Toremifene (Fareston)

Aromatase inhibitors

• Anastrozole (Arimidex)
• Exemestane (Aromasin)
• Letrozole (Femara)

Androgens

• Fluoxymesterone (Halotestin)

Anti-androgens

• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Dutasteride (Avodart)
• Enzalutamide (Xtandi)
• Flutamide (Eulexin)
• Finasteride (Proscar)
• Ketoconazole (Nizoral)
• Nilutamide (Nilandron)
• Triptorelin (Trelstar)

GnRH agonists

• Buserelin (Superfact)
• Goserelin (Zoladex)
• Leuprolide (Lupron)

GnRH antagonists

• Degarelix (Firmagon)

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Biologics

Monoclonal antibodies

Anti-CD20 antibodies

• Rituximab (Rituxan)
• Ibritumomab (Zevalin)
• Obinutuzumab (Gazyva)
• Ofatumumab (Arzerra)

Anti-CD30 antibodies

• Brentuximab (Adcetris)

Anti-CD33 antibodies

• Gemtuzumab (Mylotarg)

Anti-CD52 antibodies

• Alemtuzumab (Campath)

Anti-CTLA–4 antibodies

• Ipilimumab (Yervoy)

Anti-EGFR (ErbB1) antibodies

• Cetuximab (Erbitux)
• Panitumumab (Vectibix)

Anti-PD–1 antibodies

• Nivolumab (Opdivo)
• Pembrolizumab (Keytruda)

Anti-HER2/neu (ErbB2) antibodies

• Ado-trastuzumab emtansine (Kadcyla)
• Trastuzumab (Herceptin)

Anti-VEGF antibodies

• Bevacizumab (Avastin)

IL-2 inhibitors

• Aldesleukin (Proleukin)
• Denileukin diftitox (Ontak)

IL-6 inhibitors

• Siltuximab (Sylvant)

Immunotherapy

• Interferon alfa-2b (Intron A)

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Hematopoietic Growth Factors

Erythrocyte growth factors

• Erythropoietin (Procrit)

Granulocyte growth factors

• Filgrastim (Granix)
• Sargramostin (Leukine)
• Tbo-filgrastim (Granix)

Megakaryocyte growth factors

• Eltrombopag (Promacta)

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Supportive Medications

Chemotherapy protective agents

• Amifostine (Ethyol)
• Cyanocobalamin
• Dexrazoxane (Zinecard)
• Folinic acid (Leucovorin)
• Glucarpidase (Voraxaze)
• Levoleucovorin (Fusilev)
• Mesna (Mesnex)

Antiemetic agents

• Netupitant and palonosetron (Akynzeo)

RANK ligand inhibitors

• Denosumab (Xgeva)

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Miscellaneous

Mitotic inhibitors

• Eribulin (Halaven)
• Ixabepilone (Ixempra)

Bisphosphonates

• Zoledronic Acid (Zometa)

HDAC inhibitors

• Belinostat (Beleodaq)
• Romidepsin (Istodax)
• Vorinostat (Zolinza)

Hedgehog pathway inhibitors

• Vismodegib (Erivedge)

Immunomodulatory drugs (IMiDs)

• Everolimus (Afinitor)
• Lenalidomide (Revlimid)
• Pomalidomide (Pomalyst)

Kinase inhibitors

• Afatinib (Gliotrif)
• Cabozantinib (Cometriq)
• Crizotinib (Xalkori)
• Dasatinib (Sprycel)
• Erlotinib (Tarceva)
• Gefitinib (Iressa)
• Ibrutinib (Imbruvica)
• Idelalisib (Zydelig)
• Lapatinib (Tykerb)
• Nilotinib (Tasigna)
• Palbociclib (Ibrance)
• Sorafenib (Nexavar)
• Sunitinib (Sutent)

mTOR Inhibitors

• Temsirolimus (Torisel)
• Everolimus (Afinitor)

Proteasome inhibitors

• Bortezomib (Velcade)
• Carfilzomib (Kyprolis)

Radioactive agents

• Radium-223 chloride (Xofigo)

Somatostatin analogs

• Octreotide (Octreotide)

VEGF receptor-2 antagonists

• Ramucirumab (Cyramza)

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