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Meningitis, MRSA

• Meningitis caused by methicillin-resistant Staphylococcus aureus (MRSA)

• Preferred regimen: Vancomycin 30–45 mg/kg/day IV q8–12h for 2 weeks
• Alternative regimen: Linezolid 600 mg PO/IV q12h OR TMP-SMX 10–20 mg/kg/day IV q6–12h
• Pediatric regimen: Vancomycin 15–20 mg/kg IV q6h OR Linezolid 10 mg/kg PO/IV q8h

Note: The addition of Rifampin 600 mg qd or 300–450 mg bid to vancomycin may be considered for adult patients.