Sarcoidosis CT

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Roshan Dinparasti Saleh

Overview

In comparison with chest x-ray, HRCT is more specific and proved useful in the diagnosis of sarcoidosis and evaluation of complications, such as aspergilloma . Chest CT findings include parenchymal perilymphatic nodules.

CT

CT is useful in diagnosis of sarcoidosis[1]. A CT scoring system for sarcoidosis has been described and has been suggested to assess severity of disease.Typical HRCT findings that suggest sarcoidosis include parenchymal nodules and opacities that represent conglomerations of these nodules that have a perilymphatic distribution along the bronchovascular bundles as well as in subpleural locations[2][3][4]. Honeycombing in HRCT is associated with decreased DLcO and an increased A-a PO2 gradient[5][6]. .

Sarcoidosis bilateral peribronchial lymphadenopathy adapted from www.radiopaedia.org
Complicated sarcoidosis adapted from www.radiopaedia.org
Complicated sarcoidosis adapted from www.radiopaedia.org


References

  1. Vagal AS, Shipley R, Meyer CA: Radiological manifestations of sarcoidosis. Clinics in dermatology 2007, 25(3):312-325.
  2. Oberstein A, von Zitzewitz H, Schweden F, Muller-Quernheim J: Non invasive evaluation of the inflammatory activity in sarcoidosis with high-resolution computed tomography. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 1997, 14(1):65-72.
  3. Nishino M, Lee KS, Itoh H, Hatabu H: The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. European journal of radiology 2010, 73(1):66-73.
  4. Criado E, Sanchez M, Ramirez J, et al: Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation.
  5. Abehsera M, Valeyre D, Grenier P, Jaillet H, Battesti JP, Brauner MW: Sarcoidosis with pulmonary fibrosis: CT patterns and correlation with pulmonary function. AJR American journal of roentgenology 2000, 174(6):1751-1757.
  6. Naccache JM, Lavole A, Nunes H, Lamberto C, Letoumelin P, Brauner M, Valeyre D, Brillet PY: High-resolution computed tomographic imaging of airways in sarcoidosis patients with airflow obstruction. Journal of computer assisted tomography 2008, 32(6):905-912.

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