Sexcord/ stromal ovarian tumors laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
Laboratory findings consistent with the diagnosis of sexcord/ stromal ovarian tumors include identifying the presence or absence of tumor markers like AMH: anti-Müllerian hormone; AFP: alpha-fetoprotein; E2: estradiol; hCG: human chorionic gonadotropin; LDH: lactate dehydrogenase; testost: testosterone; andro: androstenedione; DHEA: dehydroepiandrostenedione;
Laboratory Findings
- Laboratory findings consistent with the diagnosis of sexcord-stromal ovarian tumors include identifying the tumor markers[1][2][3][4][5][6][7][8]
- The following are the tumor markers found in sexcord/stromal ovarian tumors
| Sex cord-stromal tumors | AFP | hCG | LDH | E2 | Inhibin | Testosterone | Androstenedione | DHEA | AMH |
| Thecoma-fibroma | - | - | - | - | - | - | - | - | - |
| Granulosa cell tumors | - | - | - | +/- | + | +/- | - | - | + |
| Sertoli-Leydig tumors | +/- | - | - | +/- | +/- | +/- | +/- | +/- | - |
AMH: anti-Müllerian hormone; AFP: alpha-fetoprotein; E2: estradiol; hCG: human chorionic gonadotropin; LDH: lactate dehydrogenase; testost: testosterone; andro: androstenedione; DHEA: dehydroepiandrostenedione; .
References
- ↑ Rey RA, Lhommé C, Marcillac I, Lahlou N, Duvillard P, Josso N, Bidart JM (March 1996). "Antimüllerian hormone as a serum marker of granulosa cell tumorsof the ovary: comparative study with serum alpha-inhibin and estradiol". Am. J. Obstet. Gynecol. 174 (3): 958–65. PMID 8633676.
- ↑ Robertson DM, Cahir N, Burger HG, Mamers P, Groome N (March 1999). "Inhibin forms in serum from postmenopausal women with ovarian cancers". Clin. Endocrinol. (Oxf). 50 (3): 381–6. PMID 10435065.
- ↑ Robertson DM, Stephenson T, Pruysers E, Burger HG, McCloud P, Tsigos A, Groome N, Mamers P, McNeilage J, Jobling T, Healy D (May 2002). "Inhibins/activins as diagnostic markers for ovarian cancer". Mol. Cell. Endocrinol. 191 (1): 97–103. PMID 12044923.
- ↑ Markova D, Milchev N, Batashki I, Uchikov A (2008). "[Role of total inhibin in diagnosis and monitoring of ovarian cancer in postmenopausal women]". Akush Ginekol (Sofiia) (in Bulgarian). 47 (1): 16–9. PMID 18642569.
- ↑ Robertson DM, Stephenson T, Pruysers E, McCloud P, Tsigos A, Groome N, Mamers P, Burger HG (February 2002). "Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancer". J. Clin. Endocrinol. Metab. 87 (2): 816–24. doi:10.1210/jcem.87.2.8198. PMID 11836327.
- ↑ Kurihara S, Hirakawa T, Amada S, Ariyoshi K, Nakano H (December 2004). "Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literature". J. Obstet. Gynaecol. Res. 30 (6): 439–43. doi:10.1111/j.1447-0756.2004.00231.x. PMID 15566459.
- ↑ Ran S, Yu Q, Deng S, Xu L (April 2017). "Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature". J Ovarian Res. 10 (1): 30. doi:10.1186/s13048-017-0327-2. PMC 5404692. PMID 28438188.
- ↑ Bufa A, Farkas N, Preisz Z, Poór V, Páger C, Szukits S, Farkas B, Gőcze PM (June 2017). "Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports". J Med Case Rep. 11 (1): 166. doi:10.1186/s13256-017-1324-1. PMC 5480180. PMID 28637499.