Small nuclear ribonucleoprotein polypeptide A

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.

Further reading

• Hoffman DW, Query CC, Golden BL, et al. (1991). "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins". Proc. Natl. Acad. Sci. U.S.A. 88 (6): 2495–9. Bibcode:1991PNAS...88.2495H. doi:10.1073/pnas.88.6.2495. PMC 51259. PMID 1826055.
• Nelissen RL, Sillekens PT, Beijer RP, et al. (1991). "Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein". Gene. 102 (2): 189–96. doi:10.1016/0378-1119(91)90077-O. PMID 1831431.
• Jessen TH, Oubridge C, Teo CH, et al. (1991). "Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA". EMBO J. 10 (11): 3447–56. PMC 453073. PMID 1833186.
• Nagai K, Oubridge C, Jessen TH, et al. (1991). "Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.". Nature. 348 (6301): 515–20. Bibcode:1990Natur.348..515N. doi:10.1038/348515a0. PMID 2147232.
• Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ (1988). "cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins". EMBO J. 6 (12): 3841–8. PMC 553857. PMID 2962859.
• Oubridge C, Ito N, Evans PR, et al. (1994). "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin". Nature. 372 (6505): 432–8. Bibcode:1994Natur.372..432O. doi:10.1038/372432a0. PMID 7984237.
• Howe PW, Nagai K, Neuhaus D, Varani G (1994). "NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein". EMBO J. 13 (16): 3873–81. PMC 395300. PMID 8070414.
• Allain FH, Gubser CC, Howe PW, et al. (1996). "Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation". Nature. 380 (6575): 646–50. Bibcode:1996Natur.380..646A. doi:10.1038/380646a0. PMID 8602269.
• Avis JM, Allain FH, Howe PW, et al. (1996). "Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding". J. Mol. Biol. 257 (2): 398–411. doi:10.1006/jmbi.1996.0171. PMID 8609632.
• Lu J, Hall KB (1997). "Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy". Biochemistry. 36 (34): 10393–405. doi:10.1021/bi9709811. PMID 9265619.
• Allain FH, Howe PW, Neuhaus D, Varani G (1997). "Structural basis of the RNA-binding specificity of human U1A protein". EMBO J. 16 (18): 5764–72. doi:10.1093/emboj/16.18.5764. PMC 1170207. PMID 9312034.
• Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Ferré-D'Amaré AR, Zhou K, Doudna JA (1998). "Crystal structure of a hepatitis delta virus ribozyme". Nature. 395 (6702): 567–74. Bibcode:1998Natur.395..567F. doi:10.1038/26912. PMID 9783582.
• Lutz CS, Cooke C, O'Connor JP, et al. (1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
• Hetzer M, Mattaj IW (2000). "An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins". J. Cell Biol. 148 (2): 293–303. doi:10.1083/jcb.148.2.293. PMC 2174293. PMID 10648562.
• Klein Gunnewiek JM, Hussein RI, van Aarssen Y, et al. (2000). "Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation". Mol. Cell. Biol. 20 (6): 2209–17. doi:10.1128/MCB.20.6.2209-2217.2000. PMC 110837. PMID 10688667.
• Varani L, Gunderson SI, Mattaj IW, et al. (2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nat. Struct. Biol. 7 (4): 329–35. doi:10.1038/74101. PMID 10742179.
• Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
• Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi:10.1016/S1074-7613(01)00158-3. PMID 11420046.