Small nucleolar RNA SNORD19
SNORD19 (also known as HBII-108) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD19 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1].
HBII-108 is the human orthologue of the mouse MBII-108 [2] and is predicted to guide 2'O-ribose methylation of the small subunit (SSU) ribosomal RNA (rRNA), 18S, on position G683 [3]. In the human genome snoRNA HBII-108 is located in the introns of the gene nucleostemin (NS), along with another snoRNA HBII-210.
References
- ↑ Galardi, S (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol. 22: 6663&ndash, 6668. PMID 12215523. Unknown parameter
|coauthors=ignored (help) - ↑ Huttenhofer, A (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20: 2943&ndash, 2953. PMID 11387227. Unknown parameter
|coauthors=ignored (help) - ↑ Lestrade, L (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158&ndash, D162. PMID 16381836. Unknown parameter
|coauthors=ignored (help)
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