Small nucleolar RNA snR48
snoRNA snR48 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snR48 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1][2].
snR48 was identified in yeast [Saccharomyces cerevisiae) by computational screening of the yeast genome. This snoRNA is predicted to guide the 2'O ribosose methylation of 28S ribosomal RNA (rRNA) residues Gm2788 and Gm2790. [3].
References
- ↑ Galardi, S (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol. 22: 6663&ndash, 6668. PMID 12215523. Unknown parameter
|coauthors=ignored (help) - ↑ Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. PMID 12007400.
- ↑ Lowe TM, Eddy SR (1999). "A computational screen for methylation guide snoRNAs in yeast". Science. 283 (5405): 1168–71. PMID 10024243.
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