Sorting nexin 10

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.

Further reading

• Qin B, He M, Chen X, Pei D (2006). "Sorting nexin 10 induces giant vacuoles in mammalian cells". J. Biol. Chem. 281 (48): 36891–6. doi:10.1074/jbc.M608884200. PMID 17012226.
• Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D (2012). "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo". Cell Res. 22 (2): 333–45. doi:10.1038/cr.2011.134. PMC 3271581. PMID 21844891.
• Zhu CH, Morse LR, Battaglino RA (2012). "SNX10 is required for osteoclast formation and resorption activity". J. Cell. Biochem. 113 (5): 1608–15. doi:10.1002/jcb.24029. PMID 22174188.
• Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O (2012). "An SNX10 mutation causes malignant osteopetrosis of infancy". J. Med. Genet. 49 (4): 221–6. doi:10.1136/jmedgenet-2011-100520. PMID 22499339.
• Pangrazio A, Fasth A, Sbardellati A, Orchard PJ, Kasow KA, Raza J, Albayrak C, Albayrak D, Vanakker OM, De Moerloose B, Vellodi A, Notarangelo LD, Schlack C, Strauss G, Kühl JS, Caldana E, Lo Iacono N, Susani L, Kornak U, Schulz A, Vezzoni P, Villa A, Sobacchi C (2013). "SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity". J. Bone Miner. Res. 28 (5): 1041–9. doi:10.1002/jbmr.1849. PMID 23280965.
• Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J (2013). "Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation". J. Biol. Chem. 288 (23): 16598–605. doi:10.1074/jbc.M112.449306. PMC 3675595. PMID 23615901.
• Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J (2014). "Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis". Proteins. 82 (12): 3483–9. doi:10.1002/prot.24689. PMID 25212774.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.