Sulfatase
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| File:1p49 opm.gif | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | Sulfatase | ||||||||
| Pfam | PF00884 | ||||||||
| InterPro | IPR000917 | ||||||||
| PROSITE | PDOC00117 | ||||||||
| SCOP | 1auk | ||||||||
| SUPERFAMILY | 1auk | ||||||||
| OPM superfamily | 24 | ||||||||
| OPM protein | 1p49 | ||||||||
| |||||||||
Sulfatases EC 3.1.6. are esterase enzymes which remove sulfate from a variety of substrates by hydrolyzing various sulphate esters.
The following sulphatases were shown to be structurally related based on their sequence homology[1][2],[3],
- cerebroside-sulfatase
- steryl-sulfatase
- arylsulphatase A EC 3.1.6.8 (ASA), a lysosomal enzyme which hydrolyzes cerebroside sulphate;
- arylsulphatase B EC 3.1.6.12 (ASB) which hydrolyzes the sulphate ester group from N-acetylgalactosamine 4-sulphate residues of dermatan sulphate;
- arylsulphatase C (ASD) and E (ASE); steryl-sulphatase EC 3.1.6.2 (STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy steroid sulphates;
- iduronate 2-sulphatase EC 3.1.6.13 (IDS), a lysosomal enzyme that hydrolyzes the 2-sulphate groups from iduronic acids in dermatan sulphate and heparan sulphate;
- N-acetylgalactosamine-6-sulphatase EC 3.1.6.4, which hydrolyzes the 6-sulphate groups of the N-acetyl-D-galactosamine of chondroitin sulphate and D-galactose 6-sulphate units of keratan sulphate;
- N-sulphoglucosamine sulphohydrolase EC 3.10.1.1, the lysosomal enzyme that hydrolyses N-sulpho-D-glucosamine into glucosamine and sulphate;
- glucosamine-6-sulphatase EC 3.1.6.14 (G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulphate units of heparan sulphate and keratan sulphate;
- N-sulphoglucosamine sulphohydrolase EC 3.10.1.1, the lysosomal enzyme that hydrolyses N-sulpho-D-glucosamine into glucosamine and sulphate;
- sea urchin embryo arylsulphatase EC 3.1.6.1;
- green algae arylsulphatase EC 3.1.6.1, which plays a role in the mineralization of sulphates; and
- arylsulphatase EC 3.1.6.1 from Escherichia coli, Klebsiella aerogenes and Pseudomonas aeruginosa.
Human proteins containing this domain
ARSA; ARSB; ARSD; ARSE; ARSF; ARSG; ARSH; ARSI; ARSJ; ARSK; GALNS; GNS; IDS; PIGG; SGSH; STS; SULF1; SULF2;
References
- ↑ von Figura K, Vingron M, Schmidt B, Meyer HE, Peters C, Rommerskirch W, Rupp K, Pohlmann R, Zuhlsdorf M (1990). "Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B". J. Biol. Chem. 265 (6): 3374–3381. PMID 2303452.
- ↑ Wilson PJ, Morris CP, Anson DS, Occhiodoro T, Bielicki J, Clements PR, Hopwood JJ (1990). "Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8531–8535. PMID 2122463.
- ↑ Grossman AR, de Hostos EL, Schilling J (1989). "Structure and expression of the gene encoding the periplasmic arylsulfatase of Chlamydomonas reinhardtii". Mol. Gen. Genet. 218 (2): 229–239. PMID 2476654.
External links
- Sulfatases at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview at rndsystems.com
- "Annotation of the sulfatase gene family" at mad-cow.org
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