T-cell prolymphocytic leukemia natural history, complications and prognosis
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T-cell prolymphocytic leukemia Microchapters |
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Differentiating T-cell prolymphocytic leukemia historical perspective from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]
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T-cell prolymphocytic leukemia Microchapters |
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Differentiating T-cell Prolymphocytic Leukemia from other Diseases |
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Diagnosis |
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Treatment |
|
Case Studies |
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T-cell prolymphocytic leukemia natural history, complications and prognosis On the Web |
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American Roentgen Ray Society Images of T-cell prolymphocytic leukemia natural history, complications and prognosis |
|
FDA on T-cell prolymphocytic leukemia natural history, complications and prognosis |
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CDC on T-cell prolymphocytic leukemia natural history, complications and prognosis |
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T-cell prolymphocytic leukemia natural history, complications and prognosis in the news |
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Blogs on T-cell prolymphocytic leukemia natural history, complications and prognosis |
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Directions to Hospitals Treating T-cell prolymphocytic leukemia |
Overview
T-cell prolymphocytic leukemia is diagnosed after its symptoms appear. Failure to treat can result in multiple organ failure.
Natural History, Complications and Prognosis
- The majority of patients with T-cell prolymphocytic leukemia are symptomatic at the time of diagnosis.
- Early clinical features include fever, fatigue, and lymphadenopathy.
- If left untreated, patients with T-cell prolymphocytic leukemia may progress to develop multiple organ failure.
- Common complications of T-cell prolymphocytic leukemia, include:[1]
- Prognosis is generally poor, and the median survival time of patients with T-cell prolymphocytic leukemia is approximately one to two years.[1]
- Patients with CD45RO+/CD45RA- immunophenotype tend to have a more indolent course.
- It seems following factors are associated with worse prognosis:
- Increased expression of TCL1
- Increased activity of the serine-threonine kinase AKT