This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
References
↑Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ (Mar 2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis". Nat Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID11062498.
↑Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q (Oct 2002). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides". Gene. 296 (1–2): 205–12. doi:10.1016/S0378-1119(02)00861-2. PMID12383518.
Page NM (2007). "Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides". Vascul. Pharmacol. 45 (4): 200–8. doi:10.1016/j.vph.2005.08.028. PMID16931167.
Cunningham S, O'Doherty C, Patterson C, et al. (2007). "The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis". J. Neuroimmunol. 183 (1–2): 208–13. doi:10.1016/j.jneuroim.2006.11.002. PMID17175032.
