THBS1

Thrombospondin 1
File:PBB Protein THBS1 image.jpg PDB rendering based on 1lsl.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1lsl​, 1ux6​, 1z78​, 1za4​, 2erf​, 2es3​
Identifiers
Symbols	THBS1 ; THBS; TSP; TSP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31142
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE THBS1 201110 s at tn.png
File:PBB GE THBS1 201107 s at tn.png
File:PBB GE THBS1 201108 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thrombospondin 1, also known as THBS1, is a human gene.

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.

See also

Thrombospondin

Further reading

• Roberts DD (1996). "Regulation of tumor growth and metastasis by thrombospondin-1". FASEB J. 10 (10): 1183–91. PMID 8751720.
• Adams JC (1997). "Thrombospondin-1". Int. J. Biochem. Cell Biol. 29 (6): 861–5. PMID 9304800.
• Sargiannidou I, Qiu C, Tuszynski GP (2004). "Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis". Semin. Thromb. Hemost. 30 (1): 127–36. doi:10.1055/s-2004-822977. PMID 15034804.CS1 maint: Multiple names: authors list (link)
• Esemuede N, Lee T, Pierre-Paul D; et al. (2004). "The role of thrombospondin-1 in human disease". J. Surg. Res. 122 (1): 135–42. doi:10.1016/j.jss.2004.05.015. PMID 15522326.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Z, Wang C, Prendergast GC, Pestell RG (2007). "Cyclin D1 functions in cell migration". Cell Cycle. 5 (21): 2440–2. PMID 17106256.CS1 maint: Multiple names: authors list (link)
• Roberts DD, Isenberg JS, Ridnour LA, Wink DA (2007). "Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis". Clin. Cancer Res. 13 (3): 795–8. doi:10.1158/1078-0432.CCR-06-1758. PMID 17289869.CS1 maint: Multiple names: authors list (link)
• Kaczorowski DJ, Billiar TR (2007). "Targeting CD47: NO limit on therapeutic potential". Circ. Res. 100 (5): 602–3. doi:10.1161/01.RES.0000261609.44977.25. PMID 17363705.