THBS2

Thrombospondin 2
File:PBB Protein THBS2 image.jpg PDB rendering based on 1yo8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yo8​
Identifiers
Symbols	THBS2 ; TSP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2438
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE THBS2 203083 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thrombospondin 2, also known as THBS2, is a human gene.

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.

Further reading

• Bornstein P, Kyriakides TR, Yang Z; et al. (2001). "Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis". J. Investig. Dermatol. Symp. Proc. 5 (1): 61–6. doi:10.1046/j.1087-0024.2000.00005.x. PMID 11147677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". J. Biol. Chem. 267 (35): 24921–4. PMID 1459996.CS1 maint: Multiple names: authors list (link)
• LaBell TL, Milewicz DJ, Disteche CM, Byers PH (1992). "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans". Genomics. 12 (3): 421–9. PMID 1559694.CS1 maint: Multiple names: authors list (link)
• LaBell TL, Byers PH (1993). "Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region". Genomics. 17 (1): 225–9. doi:10.1006/geno.1993.1308. PMID 8406456.
• Adolph KW, Liska DJ, Bornstein P (1997). "Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2)". Gene. 193 (1): 5–11. PMID 9249061.CS1 maint: Multiple names: authors list (link)
• Kyriakides TR, Zhu YH, Smith LT; et al. (1998). "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis". J. Cell Biol. 140 (2): 419–30. PMID 9442117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
• Carron JA, Bowler WB, Wagstaff SC, Gallagher JA (1999). "Expression of members of the thrombospondin family by human skeletal tissues and cultured cells". Biochem. Biophys. Res. Commun. 263 (2): 389–91. doi:10.1006/bbrc.1999.1380. PMID 10491303.CS1 maint: Multiple names: authors list (link)
• Bein K, Simons M (2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". J. Biol. Chem. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.
• Hawighorst T, Velasco P, Streit M; et al. (2001). "Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism". EMBO J. 20 (11): 2631–40. doi:10.1093/emboj/20.11.2631. PMID 11387198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Misenheimer TM, Hahr AJ, Harms AC; et al. (2002). "Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2". J. Biol. Chem. 276 (49): 45882–7. doi:10.1074/jbc.M104218200. PMID 11590138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93. PMID 11943589.CS1 maint: Multiple names: authors list (link)
• Li Z, Calzada MJ, Sipes JM; et al. (2002). "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior". J. Cell Biol. 157 (3): 509–19. doi:10.1083/jcb.200109098. PMID 11980922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Armstrong LC, Björkblom B, Hankenson KD; et al. (2002). "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism". Mol. Biol. Cell. 13 (6): 1893–905. doi:10.1091/mbc.E01-09-0066. . PMID 12058057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hatakeyama H, Nishizawa M, Nakagawa A; et al. (2003). "Thrombospondin expression in aldosterone-producing adenomas". Hypertens. Res. 25 (4): 523–7. PMID 12358136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boekholdt SM, Trip MD, Peters RJ; et al. (2002). "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction". Arterioscler. Thromb. Vasc. Biol. 22 (12): e24–7. PMID 12482844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kyriakides TR, Rojnuckarin P, Reidy MA; et al. (2003). "Megakaryocytes require thrombospondin-2 for normal platelet formation and function". Blood. 101 (10): 3915–23. doi:10.1182/blood.V101.10.3915. PMID 12732502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kishi M, Nakamura M, Nishimine M; et al. (2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas". Cancer Sci. 94 (6): 530–5. PMID 12824879.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)