TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2gene.[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.[3]
↑ 5.05.15.2Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID15181449.
↑Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID12768206.
↑Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
Further reading
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID10850490.
Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG (Feb 2002). "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins". European Journal of Human Genetics. 10 (2): 107–12. doi:10.1038/sj.ejhg.5200775. PMID11938440.
Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N (2003). "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers". Anticancer Research. 22 (6A): 3303–7. PMID12530079.
Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID12768206.
Loayza D, Parsons H, Donigian J, Hoke K, de Lange T (Mar 2004). "DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites". The Journal of Biological Chemistry. 279 (13): 13241–8. doi:10.1074/jbc.M312309200. PMID14715659.
Ye JZ, de Lange T (Jun 2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex". Nature Genetics. 36 (6): 618–23. doi:10.1038/ng1360. PMID15133513.
Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID15181449.
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J (Oct 2004). "TIN2 mediates functions of TRF2 at human telomeres". The Journal of Biological Chemistry. 279 (42): 43799–804. doi:10.1074/jbc.M408650200. PMID15292264.
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (Nov 2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (Dec 2004). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID15383534.
