Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158gene.[1][2][3]
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway.[3]
References
↑Hama T, Maruyama M, Katoh-Semba R, Takizawa M, Iwashima M, Nara K (Aug 2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival". J Biol Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID11399754.
↑Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, Leon J, Hara E, Serrano M (Feb 2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence". Exp Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID11822868.
Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis". Cancer Genet. Cytogenet. 167 (2): 138–44. doi:10.1016/j.cancergencyto.2005.12.002. PMID16737913.
Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors". Genes Chromosomes Cancer. 45 (6): 565–74. doi:10.1002/gcc.20319. PMID16575872.
Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1–2): 78–85. doi:10.1016/j.mrfmmm.2005.07.017. PMID16280139.
Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog. 41 (4): 197–206. doi:10.1002/mc.20055. PMID15486950.
