TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.[1]
TNFAIP8L2 is a member of the TNFAIP8 (tumor necrosis factor-α-induced protein 8, or TIPE) family that function as transfer proteins for the second messenger lipids PIP2 and PIP3. The other three family members are TNFAIP8, TNFAIP8L1 and TNFAIP8L3.[2]
Structure
The crystal structure of TIPE2 reveals that it contains a large, hydrophobic central cavity that is poised for cofactor binding.[3]
↑ 1.01.1Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMID29787979.
↑ 2.02.1Goldsmith JR, Chen YH (June 2017). "Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins". Cellular & Molecular Immunology. 14 (6): 482–487. doi:10.1038/cmi.2017.4. PMID28287114.
↑Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y (January 2009). "Crystal structure of TIPE2 provides insights into immune homeostasis". Nature Structural & Molecular Biology. 16 (1): 89–90. doi:10.1038/nsmb.1522. PMID19079267.
↑Li Z, Jia W, Niu J, Zhang L (February 2018). "Understanding the roles of negative immune regulator TIPE2 in different diseases and tumourigenesis". Histology and Histopathology: 11977. doi:10.14670/HH-11-977. PMID29480508.
↑Lou Y, Liu S (October 2011). "The TIPE (TNFAIP8) family in inflammation, immunity, and cancer". Molecular Immunology. 49 (1–2): 4–7. doi:10.1016/j.molimm.2011.08.006. PMID21924498.
