TNR (gene)

Tenascin R (restrictin, janusin)
File:PBB Protein TNR image.jpg PDB rendering based on 1tdq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1tdq​
Identifiers
Symbols	TNR ; MGC149328
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2466
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TNR 206990 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tenascin R (restrictin, janusin), also known as TNR, is a human gene.

Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]

Further reading

• Erickson HP (1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Curr. Opin. Cell Biol. 5 (5): 869–76. PMID 7694605.
• Carnemolla B, Leprini A, Borsi L; et al. (1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". J. Biol. Chem. 271 (14): 8157–60. PMID 8626505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leprini A, Gherzi R, Siri A; et al. (1997). "The human tenascin-R gene". J. Biol. Chem. 271 (49): 31251–4. PMID 8940128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao ZC, Taylor J, Montag D; et al. (1997). "Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11". Eur. J. Neurosci. 8 (4): 766–82. PMID 9081628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aspberg A, Miura R, Bourdoulous S; et al. (1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10116–21. PMID 9294172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao ZC, Hillenbrand R, Schachner M; et al. (1997). "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R". J. Neurosci. Res. 49 (6): 698–709. PMID 9335257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arrigo G, Gherzi R, Bonaglia MC; et al. (1997). "Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24". Cytogenet. Cell Genet. 78 (2): 145–6. PMID 9371410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Volkmer H, Zacharias U, Nörenberg U, Rathjen FG (1998). "Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells". J. Cell Biol. 142 (4): 1083–93. PMID 9722619.CS1 maint: Multiple names: authors list (link)
• Zamze S, Harvey DJ, Pesheva P; et al. (1999). "Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans". Glycobiology. 9 (8): 823–31. PMID 10406848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olin AI, Mörgelin M, Sasaki T; et al. (2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". J. Biol. Chem. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu XR, Huang J, Xu ZG; et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woodworth A, Pesheva P, Fiete D, Baenziger JU (2004). "Neuronal-specific synthesis and glycosylation of tenascin-R". J. Biol. Chem. 279 (11): 10413–21. doi:10.1074/jbc.M312466200. PMID 14681222.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bukalo O, Schachner M, Dityatev A (2007). "Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R". J. Neurosci. 27 (22): 6019–28. doi:10.1523/JNEUROSCI.1022-07.2007. PMID 17537973.CS1 maint: Multiple names: authors list (link)