TPP2

Tripeptidyl peptidase II
Identifiers
Symbols	TPP2 ; FLJ40359
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2471
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TPP2 203375 s at tn.png
File:PBB GE TPP2 203374 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tripeptidyl peptidase II, also known as TPP2, is a human gene.

Further reading

• Tomkinson B, Jonsson AK (1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry. 30 (1): 168–74. PMID 1670990.
• Tomkinson B, Zetterqvist O (1990). "Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin". Biochem. J. 267 (1): 149–54. PMID 1691635.
• Tomkinson B (1992). "Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II". Biomed. Biochim. Acta. 50 (4–6): 727–9. PMID 1840501.
• Tomkinson B, Wernstedt C, Hellman U, Zetterqvist O (1987). "Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7508–12. PMID 3313395.CS1 maint: Multiple names: authors list (link)
• Wilson C, Gibson AM, McDermott JR (1993). "Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain". Neurochem. Res. 18 (7): 743–9. PMID 8396212.CS1 maint: Multiple names: authors list (link)
• Martinsson T, Vujic M, Tomkinson B (1993). "Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids". Genomics. 17 (2): 493–5. doi:10.1006/geno.1993.1353. PMID 8406500.CS1 maint: Multiple names: authors list (link)
• Rose C, Vargas F, Facchinetti P; et al. (1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403–9. doi:10.1038/380403a0. PMID 8602240.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Geier E, Pfeifer G, Wilm M; et al. (1999). "A giant protease with potential to substitute for some functions of the proteasome". Science. 283 (5404): 978–81. PMID 9974389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ganellin CR, Bishop PB, Bambal RB; et al. (2000). "Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors". J. Med. Chem. 43 (4): 664–74. PMID 10691692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lévy F, Burri L, Morel S; et al. (2002). "The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases". J. Immunol. 169 (8): 4161–71. PMID 12370345.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindås AC, Tomkinson B (2005). "Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II". Gene. 345 (2): 249–57. doi:10.1016/j.gene.2004.11.042. PMID 15716107.
• Stavropoulou V, Vasquez V, Cereser B; et al. (2006). "TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints". Biochem. Biophys. Res. Commun. 346 (2): 415–25. doi:10.1016/j.bbrc.2006.05.141. PMID 16762321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• York IA, Bhutani N, Zendzian S; et al. (2006). "Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation". J. Immunol. 177 (3): 1434–43. PMID 16849449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindås AC, Tomkinson B (2007). "Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements". Gene. 393 (1–2): 62–9. doi:10.1016/j.gene.2007.01.015. PMID 17343995.