TSNAX

Translin-associated factor X
Identifiers
Symbols	TSNAX ; TRAX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4374
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TSNAX 203983 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Translin-associated factor X, also known as TSNAX, is a human gene.

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.

Further reading

• Aoki K, Ishida R, Kasai M (1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Lett. 401 (2–3): 109–12. PMID 9013868.CS1 maint: Multiple names: authors list (link)
• Millar JK, Christie S, Semple CA, Porteous DJ (2001). "Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia". Genomics. 67 (1): 69–77. doi:10.1006/geno.2000.6239. PMID 10945471.CS1 maint: Multiple names: authors list (link)
• Meng G, Aoki K, Tokura K; et al. (2000). "Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X.". J. Hum. Genet. 45 (5): 305–8. PMID 11043515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". J. Biol. Chem. 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.CS1 maint: Multiple names: authors list (link)
• Erdemir T, Bilican B, Oncel D; et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu RF, Osatomi K, Terada LS, Uyeda K (2004). "Identification of Translin/Trax complex as a glucose response element binding protein in liver". Biochim. Biophys. Acta. 1624 (1–3): 29–35. PMID 14642810.CS1 maint: Multiple names: authors list (link)
• Yang S, Cho YS, Chennathukuzhi VM; et al. (2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". J. Biol. Chem. 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.CS1 maint: Multiple names: authors list (link)
• Thomson PA, Wray NR, Millar JK; et al. (2005). "Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population". Mol. Psychiatry. 10 (7): 657–68, 616. doi:10.1038/sj.mp.4001669. PMID 15838535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta GD, Makde RD, Kamdar RP; et al. (2005). "Co-expressed recombinant human Translin-Trax complex binds DNA". FEBS Lett. 579 (14): 3141–6. doi:10.1016/j.febslet.2005.05.007. PMID 15919079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)