TSN (gene)

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Translin
File:PBB Protein TSN image.jpg
PDB rendering based on 1j1j.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols TSN ; BCLF-1; REHF-1; TRSLN
External IDs Template:OMIM5 Template:MGI HomoloGene: 3397
RNA expression pattern
File:PBB GE TSN 201504 s at tn.png
File:PBB GE TSN 201515 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Translin, also known as TSN, is a human gene.[1]

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TSN translin".

Further reading

  • Aoki K, Suzuki K, Sugano T; et al. (1995). "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations". Nat. Genet. 10 (2): 167–74. doi:10.1038/ng0695-167. PMID 7663511.
  • Kasai M, Aoki K, Matsuo Y; et al. (1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". Int. Immunol. 6 (7): 1017–25. PMID 7947454.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Aoki K, Nakahara K, Ikegawa C; et al. (1994). "Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family". Oncogene. 9 (4): 1109–15. PMID 8134113.
  • Aoki K, Ishida R, Kasai M (1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Lett. 401 (2–3): 109–12. PMID 9013868.
  • Kasai M, Matsuzaki T, Katayanagi K; et al. (1997). "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome". J. Biol. Chem. 272 (17): 11402–7. PMID 9111049.
  • Aoki K, Inazawa J, Takahashi T; et al. (1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Hasegawa T, Isobe K (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochim. Biophys. Acta. 1428 (2–3): 161–8. PMID 10434033.
  • Badge RM, Yardley J, Jeffreys AJ, Armour JA (2000). "Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination". Hum. Mol. Genet. 9 (8): 1239–44. PMID 10767349.
  • Hosaka T, Kanoe H, Nakayama T; et al. (2001). "Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6)". Oncogene. 19 (50): 5821–5. doi:10.1038/sj.onc.1203943. PMID 11126370.
  • Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA". J. Biol. Chem. 276 (16): 13256–63. doi:10.1074/jbc.M009707200. PMID 11278549.
  • Lee SP, Fuior E, Lewis MS, Han MK (2001). "Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide". Biochemistry. 40 (46): 14081–8. PMID 11705401.
  • Erdemir T, Bilican B, Oncel D; et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
  • Han MK, Lin P, Paek D; et al. (2002). "Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer". Biochemistry. 41 (10): 3468–76. PMID 11876655.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Sengupta K, Rao BJ (2003). "Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions". Biochemistry. 41 (51): 15315–26. PMID 12484770.
  • Li K, Wang L, Cheng J; et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus". World J. Gastroenterol. 9 (2): 300–3. PMID 12532453.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yang S, Cho YS, Chennathukuzhi VM; et al. (2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation". J. Biol. Chem. 279 (13): 12605–14. doi:10.1074/jbc.M313133200. PMID 14711818.

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