Tang Hsi Ryu syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Tang Hsi Ryu syndrome is a very rare disease involving skin, liver, spleen and peripheral nerves.

Pathophysiology

In Japan and United States this syndrome has been associated with plasma cell dyscrasia.

Diagnosis

Physical Examination

Skin

• Skin hyperpigmentation

Head

• Swollen lymph nodes

Abdomen

• Hepatosplenomegaly
• Ascites

Extremities

• Oedema
• White nails

Neurologic

• Polyneuropathy

Others

• Gynaecomastia