Thiamylal

Thiamylal

Clinical data
Synonyms	Thiamylal, Thioseconal, Surital
AHFS/Drugs.com	International Drug Names
ATCvet code	Template:Infobox drug/formatATCvet Template:Infobox drug/formatATCvet
Legal status
Legal status	CA: Schedule III US: Schedule III
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	14.3 h (cats)
Identifiers
IUPAC name 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS Number	77-27-0 Y
PubChem CID	3032285
DrugBank	DB01154 Y
ChemSpider	2297298 Y
UNII	01T23W89FR
KEGG	D06106 Y
ChEBI	CHEBI:9536 Y
ChEMBL	ChEMBL440 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H18N2O2S
Molar mass	254.35 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C
InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) Y Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N Y
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Evidence Based Medicine
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Clinical Trials
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News
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Commentary
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Definitions
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Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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International
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia or as an anticonvulsant to counteract side effects from other anaesthetics. It is the thiobarbiturate analogue of secobarbital.