Thoracic aortic aneurysm risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Salih, MD. [2]
Overview
Hypertension and cigarette smoking are the most important risk factors, though the importance of genetic factors in the development of thoracic aortic aneurysm (such as familial thoracic aortic aneurysm; familial aortic dissection) has been increasingly recognized. Approximately 10% of patients may have other family members who have aortic aneurysms. It is also important to note that individuals with a history of aneurysms in other parts of the body have a higher chance of developing a thoracic aortic aneurysm.
Risk Factors
Thoracic aortic aneurysm risk factors include:[1][2][3][4][5][6][7][8]
- Smoking or chewing tobacco
- High blood pressure
- Bicuspid aortic valves
- Atherosclerosis (buildup of plaque in the arteries that can damage the lining)
- Gender: Aortic aneurysms are three times more prevalent in males versus females.
- Race: Aortic aneurysms are more frequent in Caucasian individuals versus other races.
- Individuals who have a family history of aortic aneurysms have a much higher risk of rupture and tend to develop aneurysms at a younger age.
- Chronic obstructive pulmonary disease
- Previous repair of a thoracic aorta aneurysm[9]
- Turners syndrome[10]
References
- ↑ Isselbacher EM (February 2005). "Thoracic and abdominal aortic aneurysms". Circulation. 111 (6): 816–28. doi:10.1161/01.CIR.0000154569.08857.7A. PMID 15710776.
- ↑ Reed D, Reed C, Stemmermann G, Hayashi T (January 1992). "Are aortic aneurysms caused by atherosclerosis?". Circulation. 85 (1): 205–11. doi:10.1161/01.cir.85.1.205. PMID 1728451.
- ↑ Tilson MD (January 1992). "Aortic aneurysms and atherosclerosis". Circulation. 85 (1): 378–9. doi:10.1161/01.cir.85.1.378. PMID 1728475.
- ↑ Bickerstaff LK, Pairolero PC, Hollier LH, Melton LJ, Van Peenen HJ, Cherry KJ, Joyce JW, Lie JT (December 1982). "Thoracic aortic aneurysms: a population-based study". Surgery. 92 (6): 1103–8. PMID 7147188.
- ↑ Clouse WD, Hallett JW, Schaff HV, Gayari MM, Ilstrup DM, Melton LJ (December 1998). "Improved prognosis of thoracic aortic aneurysms: a population-based study". JAMA. 280 (22): 1926–9. doi:10.1001/jama.280.22.1926. PMID 9851478.
- ↑ Palmieri V, Bella JN, Arnett DK, Roman MJ, Oberman A, Kitzman DW, Hopkins PN, Paranicas M, Rao DC, Devereux RB (May 2001). "Aortic root dilatation at sinuses of valsalva and aortic regurgitation in hypertensive and normotensive subjects: The Hypertension Genetic Epidemiology Network Study". Hypertension. 37 (5): 1229–35. doi:10.1161/01.hyp.37.5.1229. PMID 11358933.
- ↑ Prakash SK, Pedroza C, Khalil YA, Milewicz DM (April 2012). "Diabetes and reduced risk for thoracic aortic aneurysms and dissections: a nationwide case-control study". J Am Heart Assoc. 1 (2). doi:10.1161/JAHA.111.000323. PMC 3487378. PMID 23130125.
- ↑ Thoracic Aortic Disease - Northwestern Memorial Hospital. Thoracic Aortic Aneurysm
- ↑ Lee JJ, Dimick JB, Williams DM, Henke PK, Deeb GM, Eagle KA, Stanley JC, Upchurch GR (October 2003). "Existence of abdominal aortic aneurysms in patients with thoracic aortic dissections". J. Vasc. Surg. 38 (4): 671–5. doi:10.1016/s0741-5214(03)00727-4. PMID 14560211.
- ↑ Gøtzsche CO, Krag-Olsen B, Nielsen J, Sørensen KE, Kristensen BO (November 1994). "Prevalence of cardiovascular malformations and association with karyotypes in Turner's syndrome". Arch. Dis. Child. 71 (5): 433–6. doi:10.1136/adc.71.5.433. PMC 1030059. PMID 7826114.