Ticarcillin Disodium and Clavulanate Potassium Injection (patient information)

About your treatment

Your doctor has ordered ticarcillin and clavulanate, an antibiotic, to help treat your infection. It will be added to an intravenous fluid that will drip through a needle or catheter placed in your vein for about 30 minutes, three to six times a day.

The combination of ticarcillin and clavulanate eliminates bacteria that cause many kinds of infections, including pneumonia and gynecological, urinary tract, skin, stomach, bone, joint, and blood infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.

Precautions

Before administering ticarcillin and clavulanate

• tell your doctor and pharmacist if you are allergic to ticarcillin, penicillin, cephalosporins [e.g., cefaclor (Ceclor), cefadroxil (Duricef), or cephalexin (Keflex)], or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antibiotics, probenecid (Benemid), and vitamins.
• tell your doctor if you have or have ever had asthma; hay fever; or kidney, liver, or gastrointestinal disease (especially colitis).
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ticarcillin and clavulanate, call your doctor.
• if you have diabetes and regularly check your urine for sugar, use Clinistix or TesTape. Do not use Clinitest tablets because this drug may cause false positive results.

Administering your medication

Before you administer ticarcillin and clavulanate, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.

It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.

Side effects

Minor Side Effects

Ticarcillin and clavulanate may cause side effects. Tell your health care provider if either of these symptoms is severe or does not go away:

• upset stomach
• diarrhea

Severe Side Effects

If you experience any of the following symptoms, call your health care provider immediately:

• rash
• itching
• fever
• chills
• facial swelling
• wheezing
• difficulty breathing
• unusual bleeding or bruising
• dizziness
• seizures
• sore mouth or throat

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].

Storing your medication

Your health care provider probably will give you a several-day supply of ticarcillin and clavulanate at a time. If you are receiving ticarcillin and clavulanate intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer. Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature. If you are told to store additional ticarcillin and clavulanate in the freezer, always move a 24-hour supply to the refrigerator for the next day's use. Do not refreeze medications.

Store your medication only as directed. Make sure you understand what you need to store your medication properly.

Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Signs of infection

If you are receiving ticarcillin and clavulanate in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:

• tenderness
• warmth
• irritation
• drainage
• redness
• swelling
• pain

Brand names

• Timentin®