Tooth and nail syndrome

Tooth and nail syndrome
ICD-10	Q82.4
OMIM	189500

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Hypodontia with nail dysgenesis; Witkop syndrome

Overview

Tooth and nail syndrome (also known as "Hypodontia with nail dysgenesis," and "Witkop syndrome") is a rare disorder, with small teeth, and small white nails that are brittle.

Historical Perspective

First described in 1965.

Pathophysiology

It is associated with MSX1.

Diagnosis

Physical Examination

Mouth

• Small teeth (hypodontia)

Extremities

• Nails that are thin, small, and friable, and which may be white (show koilonychia) at birth.

See also

• Skin lesion
• List of cutaneous conditions