Toxic megacolon laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of toxic megacolon include anemia and leukocytosis. Some patients with toxic megacolon may have elevated concentration of Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), which is usually suggestive of inflammation.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of toxic megacolon include:[1][2][3][4][5]
- Anemia
- Leukocytosis especially in patients with Clostridium difficile infection
- Hypoalbuminemia
- Metabolic alkalosis associated with a poor prognosis
- Metabolic acidosis secondary to ischemic colitis
- Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.[6][7][8][9]
- Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.[4][10][11][12]
References
- ↑ Antonopoulos P, Almyroudi M, Kolonia V, Kouris S, Troumpoukis N, Economou N (2013). "Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis". Case Rep Gastroenterol. 7 (3): 409–13. doi:10.1159/000355345. PMC 3806696. PMID 24163654.
- ↑ Caprilli R, Vernia P, Colaneri O, Torsoli A (1976). "Blood pH: a test for assessment of severity in proctocolitis". Gut. 17 (10): 763–9. PMC 1411181. PMID 12067.
- ↑ Kuroki K, Masuda A, Uehara H, Kuroki A (1998). "A new treatment for toxic megacolon". Lancet. 352 (9130): 782. PMID 9737284.
- ↑ 4.0 4.1 Strong, Scott (2010). "Management of Acute Colitis and Toxic Megacolon". Clinics in Colon and Rectal Surgery. 23 (04): 274–284. doi:10.1055/s-0030-1268254. ISSN 1531-0043.
- ↑ Autenrieth DM, Baumgart DC (2012). "Toxic megacolon". Inflamm. Bowel Dis. 18 (3): 584–91. doi:10.1002/ibd.21847. PMID 22009735.
- ↑ Brown, S. R.; Haboubi, N.; Hampton, J.; George, B.; Travis, S. P. L. (2008). "The Management of Acute Severe Colitis: ACPGBI Position Statement". Colorectal Disease. 10: 8–29. doi:10.1111/j.1463-1318.2008.01682.x. ISSN 1462-8910.
- ↑ Strong SA (2010). "Management of acute colitis and toxic megacolon". Clin Colon Rectal Surg. 23 (4): 274–84. doi:10.1055/s-0030-1268254. PMC 3134807. PMID 22131898.
- ↑ Orabona, Rossana; Valcamonico, Adriana; Salemme, Marianna; Manenti, Stefania; Tiberio, Guido AM; Frusca, Tiziana (2015). "Fulminant ulcerative colitis in a healthy pregnant woman". World Journal of Gastroenterology. 21 (19): 6060–6064. doi:10.3748/wjg.v21.i19.6060. ISSN 1007-9327.
- ↑ Chao HC, Chiu CH, Kong MS, Chang LY, Huang YC, Lin TY, Lou CC (2000). "Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon". Pediatr. Infect. Dis. J. 19 (12): 1158–62. PMID 11144376.
- ↑ Panos MZ, Wood MJ, Asquith P (1993). "Toxic megacolon: the knee-elbow position relieves bowel distension". Gut. 34 (12): 1726–7. PMC 1374472. PMID 8282262.
- ↑ Sheth SG, LaMont JT (1998). "Toxic megacolon". Lancet. 351 (9101): 509–13. doi:10.1016/S0140-6736(97)10475-5. PMID 9482465.
- ↑ {cite book | last = Koyfman | first = Alex | title = Emergency medicine images for practice : an overview of X-ray, ultrasound, CT, and MRI images | publisher = Wolters Kluwer | location = Philadelphia | year = 2016 | isbn = 9781451192209 }}