Transfusion-associated graft versus host disease history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
The clinical presentation the same as in GvHD occurring in other settings, such as bone marrow transplantation. TA-GvHD can develop four to thirty days after the transfusion. Typical symptoms include:
- fever
- erythematous maculopapular rash, which can progress to generalised erythroderma
- toxic epidermal necrolysis in extreme cases
Other symptoms can include cough, abdominal pain, vomiting, and profuse diarrhea (up to 8 liters/day).