Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2gene.[1][2] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[3]
References
↑Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry. 30 (1): 168–74. doi:10.1021/bi00215a025. PMID1670990.
↑Reits E, Neijssen J, Herberts C, et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity. 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID15084277.
External links
The MEROPS online database for peptidases and their inhibitors: S08.090
Tomkinson B (1992). "Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II". Biomed. Biochim. Acta. 50 (4–6): 727–9. PMID1840501.
Wilson C, Gibson AM, McDermott JR (1993). "Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain". Neurochem. Res. 18 (7): 743–9. doi:10.1007/BF00966768. PMID8396212.
Martinsson T, Vujic M, Tomkinson B (1993). "Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids". Genomics. 17 (2): 493–495. doi:10.1006/geno.1993.1353. PMID8406500.
Rose C, Vargas F, Facchinetti P, et al. (1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403–9. doi:10.1038/380403a0. PMID8602240.
Geier E, Pfeifer G, Wilm M, et al. (1999). "A giant protease with potential to substitute for some functions of the proteasome". Science. 283 (5404): 978–81. doi:10.1126/science.283.5404.978. PMID9974389.
Ganellin CR, Bishop PB, Bambal RB, et al. (2000). "Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors". J. Med. Chem. 43 (4): 664–74. doi:10.1021/jm990226g. PMID10691692.
Lévy F, Burri L, Morel S, et al. (2002). "The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases". J. Immunol. 169 (8): 4161–71. doi:10.4049/jimmunol.169.8.4161. PMID12370345.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Lindås AC, Tomkinson B (2005). "Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II". Gene. 345 (2): 249–257. doi:10.1016/j.gene.2004.11.042. PMID15716107.
Stavropoulou V, Vasquez V, Cereser B, et al. (2006). "TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints". Biochem. Biophys. Res. Commun. 346 (2): 415–25. doi:10.1016/j.bbrc.2006.05.141. PMID16762321.
Lindås AC, Tomkinson B (2007). "Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements". Gene. 393 (1–2): 62–69. doi:10.1016/j.gene.2007.01.015. PMID17343995.
