In molecular biology, Urothelial cancer associated 1 (non-protein coding), also known as UCA1, is a long non-coding RNA, it is upregulated in bladder cancer.[1] It is believed to function in regulation of embryonic development and in bladder cancer invasion and progression. It regulates the expression of several genes involved in tumourgenesis and/or embryonic development.[2]
↑Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006). "Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma". Clinical Cancer Research. 12 (16): 4851–8. doi:10.1158/1078-0432.CCR-06-0134. PMID16914571.
↑Wang F, Li X, Xie X, Zhao L, Chen W (2008). "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion". FEBS Letters. 582 (13): 1919–27. doi:10.1016/j.febslet.2008.05.012. PMID18501714.
Further reading
Xie XJ, Li X, Wang F, Chen W (2010). "非编码 RNA UCA1 基因的细胞定位和组织表达谱分析" [Cellular localization and tissue expression pattern of UCA1, a non-coding RNA] (PDF). 南方医科大学学报 [Journal of Southern Medical University] (in Chinese). 30 (1): 57–60. PMID20117985.CS1 maint: Unrecognized language (link)
Kaneko K, Ito Y, Ono Y, Tainaka T, Tsuchiya H, Shimoyama Y, Ando H (2011). "Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction". Journal of Pediatric Gastroenterology and Nutrition. 52 (6): 744–50. doi:10.1097/MPG.0b013e318214bd30. PMID21593646.