UCSF-SCOR trial
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Official Title
University of California San Francisco (UCSF) Arteriosclerosis Specialized Center of Research (SCOR) Intervention Trial
Objective
The objective of this study is to assess the effect of the decrease in low-density lipoprotein (LDL) by diet and drug combinations on the regression of coronary lesions.
Study Description
| Study Design | |
| Allocation | Randomized |
| Masking | Open label |
| Endpoint | Mean variation in percent area stenosis |
| Study Details | |
| Condition | Familial Hypercholesterolemia |
| Study Arms | Niacin plus colestipol +/- lovastatin (+ diet) Diet alone |
| Population Size | 72 |
Outcomes
Primary Outcome
Within patient mean variation in percent area stenosis
Publications
The decrease in LDL among patients with familial hypercholesterolemia may lead to the regression of atherosclerotic lesions in the coronary arteries.[1]
References
- ↑ Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ (1990). "Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens". JAMA. 264 (23): 3007–12. PMID 2243428.