UPK3A

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Uroplakin-3a is a protein that in humans is encoded by the UPK3A gene. It is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full. It is also found in the renal pelvis, ureter, and prostatic urethra.

Further reading

• Wu XR, Sun TT (1994). "Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein". J. Cell Sci. 106 (1): 31–43. PMID 8270634.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Lobban ED, Smith BA, Hall GD, et al. (1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
• Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
• Olsburgh J, Harnden P, Weeks R, et al. (2003). "Uroplakin gene expression in normal human tissues and locally advanced bladder cancer". J. Pathol. 199 (1): 41–9. doi:10.1002/path.1252. PMID 12474225.
• Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Koga F, Kawakami S, Fujii Y, et al. (2004). "Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder". Clin. Cancer Res. 9 (15): 5501–7. PMID 14654529.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schönfelder EM, Knüppel T, Tasic V, et al. (2006). "Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans". Am. J. Kidney Dis. 47 (6): 1004–12. doi:10.1053/j.ajkd.2006.02.177. PMID 16731295.
• Zeng Y, Wu XX, Homma Y, et al. (2007). "Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis". J. Urol. 178 (4 Pt 1): 1322–7, discussion 1327. doi:10.1016/j.juro.2007.05.125. PMID 17698128.