U wave alternans

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Related chapter: electrical alternans

Overview

U wave alternans is defined as beat to beat variation in the amplitude or axis of the U wave.

Classification

U wave alternans is one of several types of repolarization alternans which also includes ST segment alternans and T wave alternans.

Pathophysiology

The underlying molecular mechanism is thought to involve abnormalities in calcium handling.

Causes

Epidemiology and Demographics

U wave alternans is very rare.

Natural History, Complications, Prognosis

U wave alternans has been associated with an increased susceptibility to ventricular arrhythmias.^[2]^[3]

Treatment

Repletion of magnesium and calcium reversed the electrocardiographic abnormality and reduced ventricular irritability. ^[4]

References

↑ Mullican WS Jr, Fisch C: Post extrasystolic alternans of the U wave due to hypokalemia. Am Heart J 68:383, 1964.
↑ Mullican WS Jr, Fisch C: Post extrasystolic alternans of the U wave due to hypokalemia. Am Heart J 68:383, 1964.
↑ Tali Bashour; Jorge C. Rios; Patrick A. Gorman. CHEST.1973;64(3):377-379. doi:10.1378/chest.64.3.377
↑ Tali Bashour; Jorge C. Rios; Patrick A. Gorman. CHEST.1973;64(3):377-379. doi:10.1378/chest.64.3.377

[1] Mullican WS Jr, Fisch C: Post extrasystolic alternans of the U wave due to hypokalemia. Am Heart J 68:383, 1964.

[2] Mullican WS Jr, Fisch C: Post extrasystolic alternans of the U wave due to hypokalemia. Am Heart J 68:383, 1964.

[3] Tali Bashour; Jorge C. Rios; Patrick A. Gorman. CHEST.1973;64(3):377-379. doi:10.1378/chest.64.3.377

[4] Tali Bashour; Jorge C. Rios; Patrick A. Gorman. CHEST.1973;64(3):377-379. doi:10.1378/chest.64.3.377

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