Unstable angina non ST elevation myocardial infarction complications of bleeding and transfusion recommendations
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Intern Survival Guide |
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Unstable angina / NSTEMI Microchapters |
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Differentiating Unstable Angina/Non-ST Elevation Myocardial Infarction from other Disorders |
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Special Groups |
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Diagnosis |
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Laboratory Findings |
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Treatment |
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Antitplatelet Therapy |
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Additional Management Considerations for Antiplatelet and Anticoagulant Therapy |
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Risk Stratification Before Discharge for Patients With an Ischemia-Guided Strategy of NSTE-ACS |
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Mechanical Reperfusion |
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Discharge Care |
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Case Studies |
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Unstable angina non ST elevation myocardial infarction complications of bleeding and transfusion recommendations On the Web |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Template:MWT; Cafer Zorkun, M.D., Ph.D. [2]; Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.
Overview
Variability in bleeding definitions across clinical trials makes it difficult to compare the risks of different therapies; however, it is evident that there is an association between bleeding and blood transfusion, and an increased risk of adverse events including death, MI, and stroke.[1][2]
Recommendations
- Patients at high risk for bleeding complications, such as the elderly, females, and those with renal dysfunction should be identified as requiring strategies to minimize bleeding risk.[1][2]
- When an invasive strategy is employed, consideration should be given to the use of the radial artery approach.[1][2]
- Prudent dosing of antithrombotic therapy and antiplatelet therapies is essential.[1][2]
- Consideration of agents such as bivalirudin and fondaparinux, which have been shown to reduce ischemic complications while simultaneously reducing bleeding risk for a NSTEMI/unstable angina management scheme seems reasonable.[1][2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction). Circulation 2007 116: e148 – e304. PMID 17679616
- ↑ 2.0 2.1 2.2 2.3 2.4 Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS. Correction of ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction). J Am Coll Cardiol. 2008 Mar 4; 51(9): 974. PMID 17692738