User:Liqinrobin

BIOGRAPHICAL SKETCH OF Dr. QIN LI GRNERAL INFORMATIOM NAME: QIN LI

GENDER: Male

DOB: Sep. 17th,1977

MARITAL STATUS: Married

OFFICE ADDRESS 1515 Holcombe Boulevard, Unit 110 Houston, TX 77030 Office: (713) 563-9180

POSITION TITLE :Postdoc of Yan lab Department of Anesthesiology & Perioperative Medicine Center for Neuroscience & Pain Research Division of Anesthesiology & Critical Care University of Texas MD Anderson Cancer Center

CONTACT INFORMATION Email: qli4@mdanderson.org Tel: (1)832-858-8252

EDUCATION&TRAINING INSTITUTION AND LOCATION DEGREE MM/YY FIELD OF STUDY Hubei Medical College, Hubei, China M.D. 06/2000 Medicine Wuhan University, Wuhan, China M.S. 06/2006 Medicine Southern Medical University, Guangzhou, China Ph.D. 06/2010 Medicine PSU Hershey Medical College, Hershey, PA,USA Postdoc 2011-2012 Translational research of ion channel MD Anderson Cancer Center, Houston, TX,USA Postdoc 2012--- Molecular and cellular physiology of ion channel

A. Personal Statement

    I have over 10 years of expertise in and contribute to the understanding of molecular and biophysical mechanisms of ion channel activation and the translational research of disease-associated ion channel. Two ion channel families, TRP channels and BK type voltage and Ca2+ activated K+ channels have been the model systems for my studies. My research has been published in international top-tier, peer-reviewed journals including PNAS, JGP, J Neurosci, Oncology and others. One of my pioneer research is highly cited (51 cites over world), and was cited as critical proof by FDA (2013).
    In the translational studies of TRP channels, I first observe TRPM8 ion channel functionally expressed in bladder cancer, and its natural agonist, menthol, can induce the programmed death (apoptosis) of bladder cancer T24 cells directly via TRPM8 channel (Li Q et al. 2009, Oncology,77(6):335-341). And in my early postdoc program, we firstly discovered that TRPM7 and TRPM8 expression are significantly correlated with the clinical characteristics of pancreatic tumor and the malignant characteristics of pancreatic cancer(Yee et al. 2014,Cells, 3(2): 500–516; 2015, Biol Open 15; 4(4): 507–514). Recently, we found that TRPV1 /TLR4 pathway play a critical role in sensory neuron responses to Paclitaxel (Li et al. 2015,J Neurosci, 30;35(39):13487-500).
    In the study of BK channels, we systematically elucidate the molecular regulatory mechanisms of BK γ-subunits on BK channel. We have identified the critical structural and functional mechanisms of γ1-subunit to modulate BK channels (Li et al. 2015, J Gen Physiol,145(6): 543–554; 2016, J Gen Physiol,147 (4):337-351). And we also figure out the interaction part of BKαto interact with γ1-subunit (not published), and the role of the extracellular LRR loop to modulate BK channel’s activities (not published) as well. More interesting, we recently found BK channels can be conditionally induced into C-type inactivation, which provide the molecular structure to understand BK channel (Yan et al. 2016, PNAS,113(25):6991-6996). 

B. Academic Appointments /Professional Memberships

2000-2003 Surgery resident, HuaRong People’s Hospital, Yueyang, China 2010-2011 Attending urologist & Researcher Associate, Ningbo No.2 Hospital, Ningbo, China

2014-- Member, the Biophysical Society (BPS) 2016-- Member, the Society of General Physiologists (SGP) 2016-- Member, the American Association for the advancement of Science (AAAS)

C. Publications

Peer Reviewed Publications 1. Kshatri A, Li Q*, Yan J, Large RJ, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA. Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels. Channels (Austin). 2016 Jul 20:0. [Epub ahead of print] 2. Yan J, Li Q*, Aldrich RW. Closed state-coupled C-type inactivation in BK channels. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6991-6 3. Qin Li*, Guan Xin, Jiyuan Zhang, Karen Yen, Jiusheng Yan. Molecular determinants of auxiliary γ1 subunit for BK channel regulation. J Gen Physiol,2016 vol. 147 no. 4 :337-351 4. Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q*, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory NeuronResponses to TRPV1 by Activation of TLR4. J Neurosci. 2015 Sep 30;35(39):13487-500. PMID: 26424893 5. Qin Li*, Fei Fan, Ha Rim Kwak, Jiusheng Yan. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. J Gen Physiol. 2015 June; 145(6): 543–554. PMCID: PMC4442785 6. Nelson S. Yee, Abid A. Kazi, Qin Li*, Zhaohai Yang, Arthur Berg, Rosemary K. Yee. Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis. Biol Open. 2015 April 15; 4(4): 507–514. PMCID: PMC4400593 7. Nelson S. Yee, Qin Li*, Abid A. Kazi, Zhaohai Yang, Arthur Berg, Rosemary K. Yee. Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor S ize/Stage andRequirement for Cancer Cells Invasion. Cells. 2014 June; 3(2): 500–516. PMCID: PMC4092867 8. Li Q*, Wang X, Yang Z, Wang B, Li S. Menthol Induces Cell Death via the TRPM8 Channel in the Human Bladder Cancer Cell Line T24. Oncology.2009, 77(6):335-341 9. Shao siliang, leng jiangyong, Li Q*, wang weidong, zhang shun. The utilization fo FISH postoperative followup after in the patients with bladder urothelial cancer. Modern practical medicine, 2014(10):1206-1207 ［in chinese］ 10. Shao Hongxiang, Jia Guangcheng, Li Q*.The clinical analysis of chronic prostatitis during puberty with detrusor sphincter dyssyergia. Chinese Journal of Andrology, 2012,26(3):35-38［in chinese］ 11. Li Qin*,Wang X, Yang Z, Wang H, Yang z, Li S, Zheng X. Induction of cell cycle arrest in bladder cancer RT4 cells by caspaisin. Natl Med J China, 2010, 90 (18):1230-1233.］［in chinese］ 12. Sun Y, Yu DE, Li Q*. Clinical Analysis of 38 cases of female SUI patients treated with TVT-O. Chin J Clin Obstet Gynecol, 2010(11):52-53 13. Yang Z, Wang X, Wang H, Li Qin*, Liu T. Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells. Journal of Contemporary Urologic and Reproductive Oncology, 2009(6):346-350.］［in chinese］ 14. Li Qin*, Hu LQ, Wang XH, Zheng XM, Li SW. Quality-of-life in patients underwent orthotopic bladder replacement with segmental sinus-body of stomach for bladder cancer: long-term follow-up. Chinese Journal of Urology, 2007, 28(10):696-699［in chinese］ 15. ChenFeng, LiShiwen, LiQin*,Hu Liquan,Zheng Xinmin. The delayed repair of injured cavernous nerve to restore erectile function of rat. Chin J Exp Sur, 2006 ,23(9):1148［in chinese］ 16. Li Qin*, Hu Liquan, ZhengXinmin, Li Shiwen. The influence of radical cystectomy on the male erectile function and its reasons. Journal of New Medicine, 2005, 15(1):35-37［in chinese］

Book Chapters

Q. Li*, J. Yan. Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits. In: International Review of Neurobiology (Chapter2). Ed(s) Candice Contet and Maria Garcia. Elsevier: Philadelphia, PA, 2016 (128): 51–90

Internationally invited Presentation Li Q*, Zhang J, Kwak HR, Yen K, Yan J. Molecular structural determinants of BK Channel γ subunits, The 5th international ion channel conference, louzhou,Sichuan,China,6/27/2015 (presented by Dr. Yan)

Conference Abstracts and posters

1. Li Y, Pan HM, Li Q*, Kwak HR, Yan J. Charged residues on the inteacellular intersubunit assembly interface contribute to calcium-sensitivity of BK channels, Biophysical Society 58th Annual Meeting, San Francisco, CA, 2 /15 /2014 2. Li Q*, Li Y, Kwak HR, Yan J. Structural Determinants of the BK Channel γ-Subunits' Modulatory Potency. Biophysical Society 58th Annual Meeting, San Francisco, CA, 2 /15 /2014 3. Li Qin*, jiyuan zhang,Karen Yen, Jiusheng Yan. The Modulatory Function of the BK Channel γ1 Subunit is determined by its Transmembrane Domain. Biophysical Society 59th Annual Meeting, Baltimore, MD, 2/ 8 / 2015 4. Li Qin*, Jiusheng Yan. A Critical Role of the S6 Transmembrane Helix in BK Channel Modulation by Auxiliary γ Subunits. Biophysical Society 60th Annual Meeting, Los Angeles, CA, 3 / 2 / 2016 5. J Zhang, Q Li*, X Guan, HL Pan, J Yan. Structural and Functional Coupling between BK Channels and NMDA Receptors. Biophysical Society 60th Annual Meeting, Los Angeles, CA, 2/ 29 / 2016, 6. X Guan, Q Li*, J Yan. A Shared Mechanism of BK Channel Activation by Mallotoxin and Auxiliary gamma1 Subunit. Biophysical Society 60th Annual Meeting, Los Angeles, CA, 3 / 2 / 2016, 7. Li Q*, Li Y, Kwak HR, Yan J. Identification of key protein regions for the BK Channel gama-Subunits' Superior Activating Potency. Fifth Annual Translational Pain Research Symposium, Houston, TX, 4 / 4 / 2014 8. Li Qin*, jiyuan zhang,Karen Yen, Jiusheng Yan. The single Transmembrane Domain determines function of the BK Channel γ1 Subunit, Gulf coast consortia for quantitative biomedical sciences, 2015, translational pain research colloquium, Houston, TX,4/ 16/ 2015