VSNL1

Visinin-like 1
Identifiers
Symbols	VSNL1 ; HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2542
Gene ontology Molecular function Template:GNF GO
RNA expression pattern
File:PBB GE VSNL1 203797 at tn.png
File:PBB GE VSNL1 203798 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Visinin-like 1, also known as VSNL1, is a human gene.

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Further reading

• Kuno T, Kajimoto Y, Hashimoto T; et al. (1992). "cDNA cloning of a neural visinin-like Ca(2+)-binding protein". Biochem. Biophys. Res. Commun. 184 (3): 1219–25. PMID 1375457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Polymeropoulos MH, Ide S, Soares MB, Lennon GG (1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.CS1 maint: Multiple names: authors list (link)
• Lenz SE, Braunewell KH, Weise C; et al. (1996). "The neuronal EF-hand Ca(2+)-binding protein VILIP: interaction with cell membrane and actin-based cytoskeleton". Biochem. Biophys. Res. Commun. 225 (3): 1078–83. doi:10.1006/bbrc.1996.1298. PMID 8780737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997). "The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity". J. Neurochem. 68 (5): 2129–39. PMID 9109541.CS1 maint: Multiple names: authors list (link)
• Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Seq. 9 (3): 171–6. PMID 10520747.CS1 maint: Multiple names: authors list (link)
• Bernstein HG, Baumann B, Danos P; et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. PMID 10851344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braunewell KH, Brackmann M, Schaupp M; et al. (2001). "Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones". J. Neurochem. 78 (6): 1277–86. PMID 11579136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002). "The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease?". Neurobiol. Dis. 8 (5): 900–9. doi:10.1006/nbdi.2001.0432. PMID 11592857.CS1 maint: Multiple names: authors list (link)
• Bernstein HG, Braunewell KH, Spilker C; et al. (2002). "Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia". Neuroreport. 13 (4): 393–6. PMID 11930147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spilker C, Dresbach T, Braunewell KH (2002). "Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons". J. Neurosci. 22 (17): 7331–9. PMID 12196554.CS1 maint: Multiple names: authors list (link)
• Lin L, Braunewell KH, Gundelfinger ED, Anand R (2002). "Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1". Biochem. Biophys. Res. Commun. 296 (4): 827–32. PMID 12200122.CS1 maint: Multiple names: authors list (link)
• Lin L, Jeanclos EM, Treuil M; et al. (2003). "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor". J. Biol. Chem. 277 (44): 41872–8. doi:10.1074/jbc.M206857200. PMID 12202488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. PMID 12445467.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braunewell KH, Brackmann M, Manahan-Vaughan D (2003). "Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?". Neuropharmacology. 44 (6): 707–15. PMID 12681369.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez Guerrico AM, Jaffer ZM, Page RE; et al. (2005). "Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells". Oncogene. 24 (14): 2307–16. doi:10.1038/sj.onc.1208476. PMID 15735716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jheng FF, Wang L, Lee L, Chang LS (2007). "Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins". Protein J. 25 (4): 250–6. doi:10.1007/s10930-006-9008-5. PMID 16703469.CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)