Villin 1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Villin 1 is a protein that in humans is encoded by the VIL1 gene.

Function

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008].

Further reading

• Zhai L, Zhao P, Panebra A, Guerrerio AL, Khurana S (September 2001). "Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton". J. Biol. Chem. 276 (39): 36163–7. doi:10.1074/jbc.C100418200. PMID 11500485.
• Kumar N, Tomar A, Parrill AL, Khurana S (October 2004). "Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin". J. Biol. Chem. 279 (43): 45036–46. doi:10.1074/jbc.M405424200. PMID 15272027.
• Tomar A, Wang Y, Kumar N, George S, Ceacareanu B, Hassid A, Chapman KE, Aryal AM, Waters CM, Khurana S (November 2004). "Regulation of cell motility by tyrosine phosphorylated villin". Mol. Biol. Cell. 15 (11): 4807–17. doi:10.1091/mbc.e04-05-0431. PMC 524729. PMID 15342783.
• Rieder G, Tessier AJ, Qiao XT, Madison B, Gumucio DL, Merchant JL (February 2005). "Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin". J. Biol. Chem. 280 (6): 4906–12. doi:10.1074/jbc.M413399200. PMID 15576363.
• Revenu C, Courtois M, Michelot A, Sykes C, Louvard D, Robine S (March 2007). "Villin severing activity enhances actin-based motility in vivo". Mol. Biol. Cell. 18 (3): 827–38. doi:10.1091/mbc.e06-05-0423. PMC 1805090. PMID 17182858.
• Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S (February 2008). "Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia". Exp. Cell Res. 314 (3): 530–42. doi:10.1016/j.yexcr.2007.10.028. PMC 2680351. PMID 18054784.
• Khurana S, George SP (June 2008). "Regulation of cell structure and function by actin-binding proteins: villin's perspective". FEBS Lett. 582 (14): 2128–39. doi:10.1016/j.febslet.2008.02.040. PMC 2680319. PMID 18307996.
• Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H (June 2009). "Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells". Exp. Cell Res. 315 (10): 1779–89. doi:10.1016/j.yexcr.2009.01.006. PMID 19371634.
• Nakamura E, Iwakawa M, Furuta R, Ohno T, Satoh T, Nakawatari M, Ishikawa K, Imadome K, Michikawa Y, Tamaki T, Kato S, Kitagawa T, Imai T (June 2009). "Villin1, a novel diagnostic marker for cervical adenocarcinoma". Cancer Biol. Ther. 8 (12): 1146–53. PMID 19377296.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.