WBR1005
Author | [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by William J Gibson, PhD [2])]] |
---|---|
Exam Type | ExamType::USMLE Step 1 |
Main Category | MainCategory::Histology |
Sub Category | SubCategory::Endocrine |
Prompt | [[Prompt::Shown below is an image depicting the light microscopy of a paraffin embedded mouse islet. The green and red colors stain two hormones secreted by the pancreas, insulin and glucagon respectively. The blue color represents the nuclei of the cells. Which of the following types of pancreatic cells most likely correspond the the green and red colors respectively? |
Answer A | AnswerA::Delta cells and alpha cells |
Answer A Explanation | [[AnswerAExp::Delta cells produce somatostatin and alpha cells produce glucagon. Since insulin is produced in the beta cells, the insulin antibodies will label the beta cells in green. In addition, since glucagon is secreted by the alpha cells, the glucagon antibodies will label these cells in red.]] |
Answer B | AnswerB::Delta cells and beta cells |
Answer B Explanation | [[AnswerBExp::Delta cells produce somatostatin and beta cells produce insulin. Since insulin is produced in the beta cells, the insulin antibodies will label the beta cells in green. In addition, since glucagon is secreted by the alpha cells, the glucagon antibodies will label these cells in red.]] |
Answer C | AnswerC::Beta cells and delta cells |
Answer C Explanation | [[AnswerCExp::Beta cells produce insulin and delta cells produce somatostatin. Since insulin is produced in the beta cells, the insulin antibodies will label the beta cells in green. In addition, since glucagon is secreted by the alpha cells, the glucagon antibodies will label these cells in red.]] |
Answer D | AnswerD::Beta cells and alpha cells |
Answer D Explanation | [[AnswerDExp::Beta cells produce insulin and alpha cells produce glucagon. Since insulin is produced in the beta cells, the insulin antibodies will label the beta cells in green. In addition, since glucagon is secreted by the alpha cells, the glucagon antibodies will label these cells in red.]] |
Answer E | AnswerE::Alpha cells and beta cells |
Answer E Explanation | [[AnswerEExp::Alpha cells produce glucagon and beta cells produce insulin. Since insulin is produced in the beta cells, the insulin antibodies will label the beta cells in green. In addition, since glucagon is secreted by the alpha cells, the glucagon antibodies will label these cells in red.]] |
Right Answer | RightAnswer::D |
Explanation | [[Explanation::Hormones produced in the islets of Langerhans are secreted directly into the blood flow by (at least) five types of cells. In rat islets, endocrine cell subsets are distributed as follows: - Alpha cells producing glucagon (15–20% of total islet cells) |
Approved | Approved::Yes |
Keyword | WBRKeyword::Pancreas, WBRKeyword::Insulin, WBRKeyword::Glucagon, WBRKeyword::Beta cells, WBRKeyword::Histology, WBRKeyword::Immunofluorescence, WBRKeyword::Endocrine, WBRKeyword::Hormone |
Linked Question | Linked:: |
Order in Linked Questions | LinkedOrder:: |