WISP2

WNT1 inducible signaling pathway protein 2
Identifiers
Symbols	WISP2 ; CCN5; CT58; CTGF-L
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2882
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WISP2 205792 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WNT1 inducible signaling pathway protein 2, also known as WISP2, is a human gene.

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Further reading

• Pennica D, Swanson TA, Welsh JW; et al. (1999). "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14717–22. PMID 9843955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumar S, Hand AT, Connor JR; et al. (1999). "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions". J. Biol. Chem. 274 (24): 17123–31. PMID 10358067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saxena N, Banerjee S, Sengupta K; et al. (2002). "Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines". Mol. Cell. Biochem. 228 (1–2): 99–104. PMID 11855747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inadera H, Dong HY, Matsushima K (2002). "WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells". Biochem. Biophys. Res. Commun. 294 (3): 602–8. doi:10.1016/S0006-291X(02)00530-2. PMID 12056810.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Banerjee S, Saxena N, Sengupta K; et al. (2003). "WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation". Neoplasia. 5 (1): 63–73. PMID 12659671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bourdeau I, Antonini SR, Lacroix A; et al. (2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators". Oncogene. 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mason HR, Lake AC, Wubben JE; et al. (2004). "The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells". Mol. Hum. Reprod. 10 (3): 181–7. doi:10.1093/molehr/gah028. PMID 14981145.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Banerjee S, Sengupta K, Saxena NK; et al. (2005). "Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks". Mol. Cancer Res. 3 (3): 151–62. doi:10.1158/1541-7786.MCR-04-0130. PMID 15798095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka I, Morikawa M, Okuse T; et al. (2005). "Expression and regulation of WISP2 in rheumatoid arthritic synovium". Biochem. Biophys. Res. Commun. 334 (4): 973–8. doi:10.1016/j.bbrc.2005.06.196. PMID 16038875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kouzu Y, Uzawa K, Kato M; et al. (2006). "WISP-2 expression in human salivary gland tumors". Int. J. Mol. Med. 17 (4): 567–73. PMID 16525711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sengupta K, Banerjee S, Dhar K; et al. (2006). "WISP-2/CCN5 is involved as a novel signaling intermediate in phorbol ester-protein kinase Calpha-mediated breast tumor cell proliferation". Biochemistry. 45 (35): 10698–709. doi:10.1021/bi060888p. PMID 16939222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dhar G, Mehta S, Banerjee S; et al. (2007). "Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition". Cancer Lett. 254 (1): 63–70. doi:10.1016/j.canlet.2007.02.012. PMID 17383817.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davies SR, Watkins G, Mansel RE, Jiang WG (2007). "Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer". Ann. Surg. Oncol. 14 (6): 1909–18. doi:10.1245/s10434-007-9376-x. PMID 17406949.CS1 maint: Multiple names: authors list (link)