WISP3

WNT1 inducible signaling pathway protein 3
Identifiers
Symbols	WISP3 ; PPD; CCN6; LIBC; MGC125987; MGC125988; MGC125989; PPAC
External IDs	Template:OMIM5 HomoloGene: 77038
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WISP3 210861 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WNT1 inducible signaling pathway protein 3, also known as WISP3, is a human gene.

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Alternative splicing generates at least three transcript variants.

Further reading

• Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor". FEBS Lett. 327 (2): 125–30. PMID 7687569.
• Pennica D, Swanson TA, Welsh JW; et al. (1999). "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14717–22. PMID 9843955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hurvitz JR, Suwairi WM, Van Hul W; et al. (1999). "Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia". Nat. Genet. 23 (1): 94–8. doi:10.1038/12699. PMID 10471507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleer CG, Zhang Y, Pan Q; et al. (2002). "WISP3 is a novel tumor suppressor gene of inflammatory breast cancer". Oncogene. 21 (20): 3172–80. doi:10.1038/sj.onc.1205462. PMID 12082632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Sugimachi K, Shimada M; et al. (2002). "Variant WISPs as targets for gastrointestinal carcinomas". Gastroenterology. 123 (1): 392–3. PMID 12105881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao EY, Peng YQ, Zhou HD; et al. (2004). "Gene symbol: WISP3. Disease: spondyloepihyseal dysplasia tarda with progressive arthropathy". Hum. Genet. 115 (2): 174. PMID 15300987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheon H, Boyle DL, Firestein GS (2005). "Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis". J. Rheumatol. 31 (11): 2106–14. PMID 15517620.CS1 maint: Multiple names: authors list (link)
• Kutz WE, Gong Y, Warman ML (2005). "WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice". Mol. Cell. Biol. 25 (1): 414–21. doi:10.1128/MCB.25.1.414-421.2005. PMID 15601861.CS1 maint: Multiple names: authors list (link)
• Cervello M, Giannitrapani L, Labbozzetta M; et al. (2005). "Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells". Ann. N. Y. Acad. Sci. 1028: 432–9. doi:10.1196/annals.1322.051. PMID 15650268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Pan Q, Zhong H; et al. (2006). "Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells". Breast Cancer Res. 7 (6): R1080–9. doi:10.1186/bcr1351. PMID 16457688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davis L, Chen Y, Sen M (2006). "WISP-3 functions as a ligand and promotes superoxide dismutase activity". Biochem. Biophys. Res. Commun. 342 (1): 259–65. doi:10.1016/j.bbrc.2006.01.132. PMID 16480948.CS1 maint: Multiple names: authors list (link)
• Miller DS, Sen M (2007). "Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species". Biochem. Biophys. Res. Commun. 355 (1): 156–61. doi:10.1016/j.bbrc.2007.01.114. PMID 17286957.
• Yang Y, Liao E (2007). "Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA)". Med. Hypotheses. 68 (6): 1406–10. doi:10.1016/j.mehy.2006.06.046. PMID 17363178.
• Davies SR, Watkins G, Mansel RE, Jiang WG (2007). "Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer". Ann. Surg. Oncol. 14 (6): 1909–18. doi:10.1245/s10434-007-9376-x. PMID 17406949.CS1 maint: Multiple names: authors list (link)