XPC (gene)

Xeroderma pigmentosum, complementation group C
Identifiers
Symbols	XPC ; XP3; XPCC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3401
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE XPC 209375 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Xeroderma pigmentosum, complementation group C, also known as XPC, is a human gene involved in the recognition of bulky DNA adducts in Nucleotide Excision Repair.

Further reading

• Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy". Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.CS1 maint: Multiple names: authors list (link)
• El-Deiry WS (2003). "Transactivation of repair genes by BRCA1". Cancer Biol. Ther. 1 (5): 490–1. PMID 12496474.
• Sugasawa K (2007). "UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair". J. Mol. Histol. 37 (5–7): 189–202. doi:10.1007/s10735-006-9044-7. PMID 16858626.
• Legerski R, Peterson C (1993). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.". Nature. 360 (6404): 610. doi:10.1038/360610b0. PMID 1461286.
• Legerski R, Peterson C (1992). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.". Nature. 359 (6390): 70–3. doi:10.1038/359070a0. PMID 1522891.
• Legerski RJ, Liu P, Li L; et al. (1994). "Assignment of xeroderma pigmentosum group C (XPC) gene to chromosome 3p25". Genomics. 21 (1): 266–9. doi:10.1006/geno.1994.1256. PMID 8088800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Masutani C, Sugasawa K, Yanagisawa J; et al. (1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". EMBO J. 13 (8): 1831–43. PMID 8168482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li L, Bales ES, Peterson CA, Legerski RJ (1994). "Characterization of molecular defects in xeroderma pigmentosum group C.". Nat. Genet. 5 (4): 413–7. doi:10.1038/ng1293-413. PMID 8298653.CS1 maint: Multiple names: authors list (link)
• Li L, Peterson C, Legerski R (1996). "Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene". Nucleic Acids Res. 24 (6): 1026–8. PMID 8604333.CS1 maint: Multiple names: authors list (link)
• van der Spek PJ, Eker A, Rademakers S; et al. (1996). "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes". Nucleic Acids Res. 24 (13): 2551–9. PMID 8692695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts with both HHR23B and HHR23A in vivo". Mutat. Res. 383 (3): 197–203. PMID 9164480.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng L, Quilliet X, Chevallier-Lagente O; et al. (1998). "Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C.". Gene Ther. 4 (10): 1077–84. doi:10.1038/sj.gt.3300495. PMID 9415314.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khan SG, Levy HL, Legerski R; et al. (1998). "Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia". J. Invest. Dermatol. 111 (5): 791–6. doi:10.1046/j.1523-1747.1998.00391.x. PMID 9804340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokoi M, Masutani C, Maekawa T; et al. (2000). "The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA". J. Biol. Chem. 275 (13): 9870–5. PMID 10734143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Batty D, Rapic'-Otrin V, Levine AS, Wood RD (2000). "Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites". J. Mol. Biol. 300 (2): 275–90. doi:10.1006/jmbi.2000.3857. PMID 10873465.CS1 maint: Multiple names: authors list (link)
• Araújo SJ, Nigg EA, Wood RD (2001). "Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome". Mol. Cell. Biol. 21 (7): 2281–91. doi:10.1128/MCB.21.7.2281-2291.2001. PMID 11259578.CS1 maint: Multiple names: authors list (link)
• Araki M, Masutani C, Takemura M; et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. PMID 11279143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)