Zinc finger protein 182 is a protein that in humans is encoded by the ZNF182 gene .[1] [2] [3] [4]
Model organisms Model organisms have been used in the study of ZNF182 function. A conditional knockout mouse line called Zfp182tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute .[5] phenotypic screen [6] [7] [8] [9] [10] [11] [12]
Zfp182 knockout mouse phenotype
Characteristic
Phenotype
All data available at.[6] [11] [12]
Peripheral blood leukocytes 6 Weeks
Normal
Haematology Normal
Insulin
Normal
Homozygous viability at P14
Normal
Homozygous Fertility
Normal
Body weight
Normal
Neurological assessment
Normal
Grip strength
Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Eye morphology
Normal
Clinical chemistry Normal
Haematology Normal
Peripheral blood leukocytes 16 Weeks
Normal
Heart weight
Normal
Salmonella Normal
Cytotoxic T Cell Function
Normal
Spleen Immunophenotyping
Normal
Mesenteric Lymph Node Immunophenotyping
Normal
Bone Marrow Immunophenotyping
Normal
Epidermal Immune Composition
Normal
Influenza Challenge
Normal
Trichuris Challenge
Normal
References
↑ Knight JC, Grimaldi G, Thiesen HJ, Bech-Hansen NT, Fletcher CD, Coleman MP (May 1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics . 21 (1): 180–7. doi :10.1006/geno.1994.1240 . PMID 8088786 . ↑ Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering" . American Journal of Human Genetics . 48 (4): 726–40. PMC 1682948 PMID 2014798 . ↑ Wang R, Cukerman E, Heng HH, Liew CC (May 1996). "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics . 22 (3): 237–9. doi :10.1007/BF02369914 . PMID 8914609 . ↑ "Entrez Gene: ZNF182 zinc finger protein 182" .↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . ↑ 6.0 6.1 "International Mouse Phenotyping Consortium" .↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium" .↑ 12.0 12.1 "OBCD Consortium" .
Further reading
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist . 2 (4): 363–74. PMID 2288909 .