DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2gene.[1][2]
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[2]
Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer". Cancer Res. 60 (19): 5529–35. PMID11034098.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2003). "Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia". Int. J. Cancer. 106 (2): 224–31. doi:10.1002/ijc.11200. PMID12800198.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2004). "mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies". Int. J. Cancer. 108 (5): 704–11. doi:10.1002/ijc.11623. PMID14696097.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hundley HA, Walter W, Bairstow S, Craig EA (2005). "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous". Science. 308 (5724): 1032–4. doi:10.1126/science.1109247. PMID15802566.
