Zinc finger and scan domain containing 4

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene.

Function

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).

Further reading

• Lee K, Gollahon LS (2014). "Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status". Cancer Biol. Ther. 15 (8): 1094–105. doi:10.4161/cbt.29220. PMC 4119077. PMID 24840609.
• Lee K, Gollahon LS (2015). "ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity". Biochem. Biophys. Res. Commun. 466 (4): 644–9. doi:10.1016/j.bbrc.2015.09.107. PMID 26403970.
• Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS (2017). "Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos". In Vitro Cell. Dev. Biol. Anim. 53 (2): 179–190. doi:10.1007/s11626-016-0097-y. PMC 5311086. PMID 27699651.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.