Zonadhesin (gene/pseudogene)

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Zonadhesin (gene/pseudogene) is a protein that in humans is encoded by the ZAN gene.

Function

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015].

Further reading

• Gasper J, Swanson WJ (November 2006). "Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution". Am. J. Hum. Genet. 79 (5): 820–30. doi:10.1086/508473. PMC 1698559. PMID 17033959.
• Gnanasekar M, Suleman FG, Ramaswamy K, Caldwell JD (October 2009). "Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening". Int. J. Mol. Med. 24 (4): 421–6. PMID 19724880.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.