View source for ATP2B4

{{Infobox_gene}}
'''Plasma membrane calcium-transporting ATPase 4''' is an [[enzyme]] that in humans is encoded by the ''ATP2B4'' [[gene]].<ref name="pmid1674727">{{cite journal | vauthors = Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW | title = Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23 | journal = Genomics | volume = 9 | issue = 4 | pages = 629–41 |date=Jul 1991 | pmid = 1674727 | pmc = | doi =10.1016/0888-7543(91)90356-J }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=493| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by [[alternative splicing]] of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
}}

==Interactions==
ATP2B4 has been shown to [[Protein-protein interaction|interact]] with [[CASK]].<ref name=pmid12511555>{{cite journal |last=Schuh |first=Kai |author2=Uldrijan Stjepan |author3=Gambaryan Stepan |author4=Roethlein Nicola |author5=Neyses Ludwig  |date=Mar 2003 |title=Interaction of the plasma membrane Ca<sup>2+</sup> pump 4b/CI with the Ca<sup>2+</sup>/calmodulin-dependent membrane-associated kinase CASK |journal=J. Biol. Chem. |volume=278 |issue=11 |pages=9778–83 |publisher= |location = United States| issn = 0021-9258| pmid = 12511555 |doi = 10.1074/jbc.M212507200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal | vauthors=Møller JV, Juul B, le Maire M |title=Structural organization, ion transport, and energy transduction of P-type ATPases |journal=Biochim. Biophys. Acta |volume=1286 |issue= 1 |pages= 1–51 |year= 1996 |pmid= 8634322 |doi= 10.1016/0304-4157(95)00017-8}}
*{{cite journal | vauthors=Strehler EE, Zacharias DA |title=Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps |journal=Physiol. Rev. |volume=81 |issue= 1 |pages= 21–50 |year= 2001 |pmid= 11152753 |doi= }}
*{{cite journal | vauthors=Strehler EE, Treiman M |title=Calcium pumps of plasma membrane and cell interior |journal=Curr. Mol. Med. |volume=4 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 15101689 |doi=10.2174/1566524043360735 }}
*{{cite journal | author=Heim R |title=Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 333–40 |year= 1992 |pmid= 1313367 |doi=10.1111/j.1432-1033.1992.tb16784.x |name-list-format=vanc| author2=Hug M | author3=Iwata T | display-authors=3 | last4=Strehler | first4=Emanuel E. | last5=Carafoli | first5=Ernesto }}
*{{cite journal | author=Brandt P |title=Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels |journal=J. Biol. Chem. |volume=267 |issue= 7 |pages= 4376–85 |year= 1992 |pmid= 1531651 |doi= |name-list-format=vanc| author2=Neve RL | author3=Kammesheidt A | display-authors=3 | last4=Rhoads | first4=RE | last5=Vanaman | first5=TC }}
*{{cite journal | author=Strehler EE |title=Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2835–42 |year= 1990 |pmid= 2137451 |doi= |name-list-format=vanc| author2=James P | author3=Fischer R | display-authors=3 | last4=Heim | first4=R | last5=Vorherr | first5=T | last6=Filoteo | first6=AG | last7=Penniston | first7=JT | last8=Carafoli | first8=E }}
*{{cite journal | author=James P |title=Identification and primary structure of a calmodulin binding domain of the Ca<sup>2+</sup> pump of human erythrocytes |journal=J. Biol. Chem. |volume=263 |issue= 6 |pages= 2905–10 |year= 1988 |pmid= 2963820 |doi= |name-list-format=vanc| author2=Maeda M | author3=Fischer R | display-authors=3 | last4=Verma | first4=AK | last5=Krebs | first5=J | last6=Penniston | first6=JT | last7=Carafoli | first7=E }}
*{{cite journal | author=Brandt P |title=A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca<sup>2+</sup>-pumping ATPase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 9 |pages= 2914–8 |year= 1988 |pmid= 2966397 |doi=10.1073/pnas.85.9.2914 | pmc=280113 |name-list-format=vanc| author2=Zurini M | author3=Neve RL | display-authors=3 | last4=Rhoads | first4=RE | last5=Vanaman | first5=TC }}
*{{cite journal | vauthors=Howard A, Barley NF, Legon S, Walters JR |title=Plasma-membrane calcium-pump isoforms in human and rat liver |journal=Biochem. J. |volume=303 |issue= Pt 1|pages= 275–9 |year= 1994 |pmid= 7945253 |doi= 10.1042/bj3030275| pmc=1137587 }}
*{{cite journal | vauthors=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 32022 |year= 1995 |pmid= 7989379 |doi= }}
*{{cite journal | vauthors=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25993–6003 |year= 1994 |pmid= 8245032 |doi= }}
*{{cite journal | vauthors=Váradi A, Molnár E, Ashcroft SJ |title=A unique combination of plasma membrane Ca<sup>2+</sup>-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines |journal=Biochem. J. |volume=314 |issue= Pt 2|pages= 663–9 |year= 1996 |pmid= 8670083 |doi= 10.1042/bj3140663| pmc=1217098 }}
*{{cite journal | vauthors=Santiago-García J, Mas-Oliva J, Saavedra D, Zarain-Herzberg A |title=Analysis of mRNA expression and cloning of a novel plasma membrane Ca<sup>2+</sup>-ATPase splice variant in human heart |journal=Mol. Cell. Biochem. |volume=155 |issue= 2 |pages= 173–82 |year= 1996 |pmid= 8700162 |doi=10.1007/BF00229314 }}
*{{cite journal | vauthors=Zacharias DA, DeMarco SJ, Strehler EE |title=mRNA expression of the four isoforms of the human plasma membrane Ca<sup>2+</sup>-ATPase in the human hippocampus |journal=Brain Res. Mol. Brain Res. |volume=45 |issue= 1 |pages= 173–6 |year= 1997 |pmid= 9105688 |doi=10.1016/S0169-328X(97)00009-0 }}
*{{cite journal | vauthors=Dean WL, Chen D, Brandt PC, Vanaman TC |title=Regulation of platelet plasma membrane Ca<sup>2+</sup>-ATPase by cAMP-dependent and tyrosine phosphorylation |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15113–9 |year= 1997 |pmid= 9182531 |doi=10.1074/jbc.272.24.15113 }}
*{{cite journal | author=Kim E |title=Plasma membrane Ca<sup>2+</sup> ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1591–5 |year= 1998 |pmid= 9430700 |doi=10.1074/jbc.273.3.1591 |name-list-format=vanc| author2=DeMarco SJ | author3=Marfatia SM | display-authors=3 | last4=Chishti | first4=AH | last5=Sheng | first5=M | last6=Strehler | first6=EE }}
*{{cite journal | author=Guerini D |title=The expression of plasma membrane Ca<sup>2+</sup> pump isoforms in cerebellar granule neurons is modulated by Ca<sup>2+</sup> |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1667–76 |year= 1999 |pmid= 9880546 |doi=10.1074/jbc.274.3.1667 |name-list-format=vanc| author2=García-Martin E | author3=Gerber A | display-authors=3 | last4=Volbracht | first4=C | last5=Leist | first5=M | last6=Merino | first6=CG | last7=Carafoli | first7=E }}
*{{cite journal | vauthors=Rosado JA, Sage SO |title=Regulation of plasma membrane Ca<sup>2+</sup>-ATPase by small GTPases and phosphoinositides in human platelets |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19529–35 |year= 2000 |pmid= 10748016 |doi= 10.1074/jbc.M001319200 }}
}}
{{refend}}

==External links==
* {{UCSC gene info|ATP2B2}}
* {{UCSC gene info|ATP2B4}}
{{ATPases}}
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