View source for Hydroxyzine/reference table

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| style="font-size:15px; text-align: center;" | '''General classification'''
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* Antihistamine -- Competitive antagonist of histamine, H<sub>1</sub> histamine receptor and antiemetic, anxiolytic.
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| style="font-size:15px; text-align: center;" | '''Prescriptive conditions'''
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* Alcohol withdrawal anxiety
* Anxiety manifested by organic disease states
* Nausea or nauseating conditions
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| style="font-size:15px; text-align: center;" | '''Forms'''
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* Syrup
* Oral Suspension
* Tablet form
* Capsule form
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| style="font-size:15px; text-align: center;" | '''Onset and duration'''
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* ''Oral administration onset'': 15-30 minutes<ref>Usdin Yasuda S et al. Chlorpheniramine plasma concentration and histamine H<sub>1</sub>-receptor occupancy. Clin Pharmacol Ther 1995;58:210-20.</ref>
* ''Suppression of wheal & flare response to allergenic skin extract'': 4 days.<ref>Gendreau-Reid L et al. Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on
histamine-induced wheals and flares in humans. J Allergy Clin Immunol 1986;77:335-40.</ref>
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| style="font-size:15px; text-align: center;" | '''Serum level'''
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*''[[Pruritus]]'': 6-42 μg/L (14-102 nmol/L) (''Suppresses pruritus in children'')<ref>Simons FER et al. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr1984;104:123μ7.</ref>
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| style="font-size:15px; text-align: center;" | '''Fate'''
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== Peak serum level ==
* Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose
* Primary biliary cirrhosis'' -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose

== V<sub>d</sub> ==
* Children -- 19 ±9 L/kg
* Healthy adults -- 16 ± 3 L/kg
* Elderly  -- 23 ± 6 L/kg
* Primary biliary cirrhosis -- 23 ±13 L/kg

== Cl ==
* Children -- 1.9 L/hr/kg
* Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg
* Primary biliary cirrhosis --  0.5 ±0.4 L/hr/kg

== t<sub>½</sub> ==
* Children -- 7hr (increases with age)
* Healthy adults -- 20 ± 4 hr
* Elderly -- 29 ± 10 hr
* Primary biliary cirrhosis -- 37 ±13 hr
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==References==
{{reflist|2}}
[[Category:H1 receptor antagonists]]
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