View source for MYT1

{{Use dmy dates|date=April 2013}}
{{Infobox_gene}}
'''Myelin transcription factor 1''' is a [[protein]] that in humans is encoded by the ''MYT1'' [[gene]].<ref name="pmid1280325">{{cite journal | vauthors = Kim JG, Hudson LD | title = Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene | journal = Molecular and Cellular Biology | volume = 12 | issue = 12 | pages = 5632–9 | date = Dec 1992 | pmid = 1280325 | pmc = 360502 | doi =  10.1128/mcb.12.12.5632}}</ref><ref name="pmid9268380">{{cite journal | vauthors = Booher RN, Holman PS, Fattaey A | title = Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity | journal = The Journal of Biological Chemistry | volume = 272 | issue = 35 | pages = 22300–6 | date = Aug 1997 | pmid = 9268380 | pmc =  | doi = 10.1074/jbc.272.35.22300 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYT1 myelin transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661| accessdate = }}</ref>

== Function ==

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.<ref name="entrez" />

== Interactive pathway map ==
{{MECP2andAssociatedRettSyndrome_WP3584|highlight=MYT1}}

== Interactions ==

MYT1 has been shown to [[Protein-protein interaction|interact]] with [[PIN1]].<ref name=pmid10504341>{{cite journal | vauthors = Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T | title = The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression | journal = Journal of Cell Science | volume = 112 | issue = 19 | pages = 3361–71 | date = Oct 1999 | pmid = 10504341 }}</ref>

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M | title = Plasticity in the adult human oligodendrocyte lineage | journal = The Journal of Neuroscience | volume = 14 | issue = 8 | pages = 4571–87 | date = Aug 1994 | pmid = 7519254 | doi =  }}
* {{cite journal | vauthors = Armstrong RC, Kim JG, Hudson LD | title = Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes | journal = Glia | volume = 14 | issue = 4 | pages = 303–21 | date = Aug 1995 | pmid = 8530187 | doi = 10.1002/glia.440140407 }}
* {{cite journal | vauthors = Liu F, Stanton JJ, Wu Z, Piwnica-Worms H | title = The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex | journal = Molecular and Cellular Biology | volume = 17 | issue = 2 | pages = 571–83 | date = Feb 1997 | pmid = 9001210 | pmc = 231782 | doi =  10.1128/mcb.17.2.571}}
* {{cite journal | vauthors = Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD | title = Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system | journal = Journal of Neuroscience Research | volume = 50 | issue = 2 | pages = 272–90 | date = Oct 1997 | pmid = 9373037 | doi = 10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
* {{cite journal | vauthors = Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S | title = Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia | journal = Brain Research. Developmental Brain Research | volume = 140 | issue = 1 | pages = 85–92 | date = Jan 2003 | pmid = 12524179 | doi = 10.1016/S0165-3806(02)00585-0 }}
* {{cite journal | vauthors = Nielsen JA, Berndt JA, Hudson LD, Armstrong RC | title = Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells | journal = Molecular and Cellular Neurosciences | volume = 25 | issue = 1 | pages = 111–23 | date = Jan 2004 | pmid = 14962745 | doi = 10.1016/j.mcn.2003.10.001 }}
* {{cite journal | vauthors = Vana AC, Lucchinetti CF, Le TQ, Armstrong RC | title = Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS | journal = Glia | volume = 55 | issue = 7 | pages = 687–97 | date = May 2007 | pmid = 17330875 | pmc = 2789289 | doi = 10.1002/glia.20492 }}
{{refend}}

== External links ==
* {{MeshName|MYT1+protein,+human}}

{{NLM content}}
{{Transcription factors|g2}}

[[Category:Transcription factors]]


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