MYT1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

Interactive pathway map

Click on genes, proteins and metabolites below to visit related articles.

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|{{{bSize}}}px|alt=MECP2 and associated Rett Syndrome edit]]

MECP2 and associated Rett Syndrome edit

Interactions

MYT1 has been shown to interact with PIN1.

Further reading

• Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (Aug 1994). "Plasticity in the adult human oligodendrocyte lineage". The Journal of Neuroscience. 14 (8): 4571–87. PMID 7519254.
• Armstrong RC, Kim JG, Hudson LD (Aug 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia. 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.
• Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Molecular and Cellular Biology. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
• Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (Oct 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". Journal of Neuroscience Research. 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (Jan 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research. 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
• Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (Jan 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
• Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia. 55 (7): 687–97. doi:10.1002/glia.20492. PMC 2789289. PMID 17330875.

External links

• MYT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.